Gibco™ Human BMP-6 Recombinant Protein, PeproTech®

Catalog No.	Quantity
12006100UG	100 μg
120-06-10UG	10 μg
12-006-01M	2 x 500 μg
12006250UG	250 μg
120-06-2UG	2 μg
12006500UG	500 μg
120-06-50UG	50 μg

Catalog No. 12006100UG Supplier Gibco™ Supplier No. 12006100UG

Description

Recombinant Protein

120-06-1MG will be provided as 2 x 500 μg (120-06-500UG). Recombinant Human BMP-6 is a 26.2 kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 397 to 513 of the full-length BMP-6 precursor. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

BMP6 is a member of bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, Bmp6 has a proposed role in early development. In addition, the fact that BMP6 is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.

Specifications

• Accession Number: P22004
• For Use With (Application): Control, Bioactivity
• Formulation: Protein with no preservative
• Gene ID (Entrez): 654
• Molecular Weight (g/mol): 26.2 kDa
• Name: Human BMP-6
• Purification Method: Purified
• Quantity: 100 μg
• Source: HEK293 cells
• Storage Requirements: -20°C
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/μg
• Gene Alias: BMP; BMP 6; BMP6; BMP-6; Bone morphogenetic protein; Bone morphogenetic protein 6; D13Wsu115e; vegetal related growth factor (TGFB-related); vegetal-related (TGFB related) cytokine; VG-1-R; VG-1-related protein; Vg1-related sequence; Vgr; Vgr1; VGR-1
• Common Name: BMP6
• Gene Symbol: BMP6
• Biological Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 this effect is 0.03-0.06 ug/ml
• Product Type: Protein
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: VSSASDYNSS ELKTACRKHE LYVSFQDLGW QDWIIAPKGY AANYCDGECS FPLNAHMNAT NHAIVQTLVH LMNPEYVPKP CCAPTKLNAI SVLYFDDNSN VILKKYRNMV VRACGCH
• Content And Storage: -20°C
• Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 this effect is 0.03-0.06 ug/ml.
• Expression System: HEK293 cells
• Form: Lyophilized
• Purity or Quality Grade: ≥ 95% by SDS-PAGE gel and HPLC analyses.