Invitrogen™ Human BMPR1A (ALK-3) Fc Chimera Recombinant Protein

Description

Recombinant Protein

BMPR1A is a Type I member of the TGF beta receptor superfamily of transmembrane ser/thr kinases which phosphorylates intracellular SMADs in response to bone morphogenic proteins. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

Specifications

• Accession Number: P36894
• For Use With (Application): Control
• Formulation: PBS with no preservative
• Gene ID (Entrez): 657
• Molecular Weight (g/mol): 40.4 kDa
• Name: Human BMPR1A (ALK-3) Fc Chimera
• Quantity: 500 μg
• Source: CHO cells
• Regulatory Status: RUO
• Endotoxin Concentration: ≤1 EU/μg
• Gene Alias: 10q23del; 1110037I22Rik; activin A receptor, type II-like kinase 3; activin receptor-like kinase 3; ACVRLK3; ALK3; ALK-3; AU045487; BMP type-1 A receptor; BMP-2/BMP-4 receptor; Bmpr; Bmpr1a; BMPR-1 A; BMPRIA; BMPR-IA; Bone morphogenetic protein 4 receptor; bone morphogenetic protein receptor type 1 A; bone morphogenetic protein receptor type IA; bone morphogenetic protein receptor type-1 A; bone morphogenetic protein receptor, type 1 A; bone morphogenetic protein receptor, type IA; CD292; Serine/threonine-protein kinase receptor R5; SKR5
• Common Name: BMPR1A
• Gene Symbol: BMPR1A
• Biological Activity: ED50 = 120 ng/mL; determined by the dose-dependent inhibition of human BMP-4-induced alkaline phosphatase production by ATDC5 cells.
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: Recombinant human BMPR1A is a homodimer containing two 362 amino acid subunits with a C-terminal linker (IEGRMD) and a human IgG1 Fc-tag (AA Sequence: QNLDSMLHGT GMKSDSDQKK SENGVTLAPE DTLPFLKCYC SGHCPDDAIN NTCITNGHCF AIIEEDDQGE TTLASGCMKY EGSDFQCKDS PKAQLRRTIE CCRTNLCNQY LQPTLPPVVI GPFFDGSIRI EGRMDDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GK)
• Content And Storage: -20°C
• Expression System: CHO cells
• Form: Lyophilized
• Purity or Quality Grade: >95% by SDS-Page