Invitrogen™ Human CD200 His-tag Recombinant Protein

Catalog No.	Quantity
PIRP87981	1 mg
PIRP87980	100 μg

Catalog No. PIRP87981 Supplier Invitrogen™ Supplier No. RP87981

Description

Recombinant Protein

It is recommended that the protein be aliquoted for optimal storage. Reconstituted with sterile deionized water to 0.25 mg/mL. Concentration is measured by UV.

CD200 is a type-1 membrane glycoprotein in the immunoglobulin superfamily, featuring two immunoglobulin domains. It is widely expressed on various cells, including B and T cells, keratinocytes, nerve cells, follicular dendritic cells, ovarian cells, and trophoblasts. CD200 interacts with CD200R on myeloid cells, inhibiting macrophage activation, reducing IL-6 production, and attenuating lymphocyte activation. It also prevents mast cell degranulation and decreases TNF-alpha and IL-13 secretion, playing a role in immune regulation and maternal tolerance. Homologues of CD200 are found in herpesviruses and poxviruses, indicating a conserved immune modulation function. CD200 has multiple alternatively spliced transcript variants, contributing to its functional diversity. Diseases linked to CD200 dysfunction include Mantle Cell Lymphoma and Primary Hypertrophic Osteoarthropathy, highlighting its importance in health and disease.

Specifications

• Accession Number: P41217
• For Use With (Application): Control, ELISA Standard, Binding Assay
• Format: Lyophilized
• Formulation: PBS with 5% mannitol, 5% trehalose, 0.01% Tween 80 and no preservative; pH 7.4
• Gene ID (Entrez): 4345
• Molecular Weight (g/mol): 40-45 kDa
• Name: Human CD200 His-tag
• pH Range: 7.4
• Purification Method: Purified
• Quantity: 1 mg
• Storage Requirements: -20°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Endotoxin Concentration: <1.0 EU/μg
• Gene Alias: antigen identified by monoclonal antibody MRC OX-2; CD200; Cd200 antigen; Cd200 molecule; cell surface protein (thymocyte antigen identified by monoclonal antibody MRC-OX2); Cspmo2; hypothetical protein LOC534910; MOX1; MOX2; MRC; MRC OX-2 antigen; MRCOX2; My033; OX2; OX-2; OX-2 membrane glycoprotein
• Common Name: CD200
• Gene Symbol: Cd200
• Biological Activity: Immobilized CD200 Protein, Human, Recombinant (His Tag) (at 2 μg/mL (100 μL/well) can bind CD200R Protein, Human, Recombinant (His and hFc Tag), the EC50 is 5-28 ng/mL)
• Product Type: Protein
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Protein Tag: His-tag
• Sequence: Human CD200, amino acids Met1-Gly232 (Accession # NP_005935.4) with a C-terminal His-tag
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Activity: Immobilized CD200 Protein, Human, Recombinant (His Tag) at 2 μg/mL (100 μL/well) can bind CD200R Protein, Human, Recombinant (His and hFc Tag), the EC50 is 5-28 ng/mL.
• Expression System: HEK293 cells
• Form: Lyophilized
• Purity or Quality Grade: >98% as determined by SDS-PAGE.