Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Recombinant Proteins
  4. Gibco™ Human CDNF Recombinant Protein, PeproTech® 

Gibco™ Human CDNF Recombinant Protein, PeproTech®

Catalog No. 45005500UG
Encompass_Preferred
Change view
Click to view available options
Quantity:
1 mg
100 μg
25 μg
250 μg
5 μg
500 μg
6 product options available for selection
Product selection table with 6 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
45005500UG 500 μg
45005100UG 100 μg
450-05-1MG 1 mg
45005250UG 250 μg
450-05-25UG 25 μg
450-05-5UG 5 μg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 6 options available.
6 options
This item is not returnable. View return policy
Catalog No. 45005500UG Supplier Gibco™ Supplier No. 45005500UG
Add to Cart
Add to Cart
This item is not returnable. View return policy

Description

Recombinant Protein

Recombinant Human CDNF is an 18.5 kDa protein consisting of 162 amino acids, including 8 cysteine residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and highly homologous to the mesencephalic-astrocyte-derived neuro-trophic factor. Somewhat surprisingly, CDCF is expressed at higher levels in tissues such as heart, skeletal muscle and testes than in brain. Similar to the glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent the 6-hydroxylamine (6 OHDA) induced degeneration of dopaminergic neurons in a rat model of Parkinsons disease. Furthermore, CDNF was able to restore the dopaminergic function and prevent the degeneration of dopaminergic neurons in the substantia nigra, suggesting that CDNF might be suitable for the treatment of Parkinsons disease. At least two isoforms of CDNF are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q49AH0
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 441549
Molecular Weight (g/mol) 18.5 kDa
Name Human CDNF
Quantity 500 μg
Source E. coli
Regulatory Status RUO
Endotoxin Concentration <1 EU/ μg
Gene Alias 9330140G23; arginine-rich protein mutated in early stage tumors-like 1; arginine-rich, mutated in early stage tumors-like 1; ARMETL1; ARMET-like protein 1; Cdnf; Cerebral dopamine neurotrophic factor; conserved dopamine neurotrophic factor
Common Name CDNF
Gene Symbol Cdnf
Biological Activity Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 15-25 ug/ml
Conjugate Unconjugated
Recombinant Recombinant
Sequence MQEAGGRPGA DCEVCKEFLN RFYKSLIDRG VNFSLDTIEK ELISFCLDTK GKENRLCYYL GATKDAATKI LSEVTRPMSV HMPAMKICEK LKKLDSQICE LKYEKTLDLA SVDLRKMRVA ELKQILHSWG EECRACAEKT DYVNLIQELA PKYAATHPKT EL
Content And Storage -20°C
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.