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Gibco™ Human CDNF Recombinant Protein, PeproTech®

Catalog No. 45005500UG
Encompass_Preferred
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Quantity:
1 mg
100 μg
25 μg
250 μg
5 μg
500 μg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Recombinant Protein

Recombinant Human CDNF is an 18.5 kDa protein consisting of 162 amino acids, including 8 cysteine residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and highly homologous to the mesencephalic-astrocyte-derived neuro-trophic factor. Somewhat surprisingly, CDCF is expressed at higher levels in tissues such as heart, skeletal muscle and testes than in brain. Similar to the glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent the 6-hydroxylamine (6 OHDA) induced degeneration of dopaminergic neurons in a rat model of Parkinsons disease. Furthermore, CDNF was able to restore the dopaminergic function and prevent the degeneration of dopaminergic neurons in the substantia nigra, suggesting that CDNF might be suitable for the treatment of Parkinsons disease. At least two isoforms of CDNF are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q49AH0
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 441549
Molecular Weight (g/mol) 18.5 kDa
Name Human CDNF
Quantity 500 μg
Source E. coli
Regulatory Status RUO
Endotoxin Concentration <1 EU/ μg
Gene Alias 9330140G23; arginine-rich protein mutated in early stage tumors-like 1; arginine-rich, mutated in early stage tumors-like 1; ARMETL1; ARMET-like protein 1; Cdnf; Cerebral dopamine neurotrophic factor; conserved dopamine neurotrophic factor
Common Name CDNF
Gene Symbol Cdnf
Biological Activity Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 15-25 ug/ml
Conjugate Unconjugated
Recombinant Recombinant
Sequence MQEAGGRPGA DCEVCKEFLN RFYKSLIDRG VNFSLDTIEK ELISFCLDTK GKENRLCYYL GATKDAATKI LSEVTRPMSV HMPAMKICEK LKKLDSQICE LKYEKTLDLA SVDLRKMRVA ELKQILHSWG EECRACAEKT DYVNLIQELA PKYAATHPKT EL
Content And Storage -20°C
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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