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Invitrogen™ Human Cytokeratin 18/KRT18 ELISA Kit

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Quantity:
5 x 96 Tests
96 Tests
Description
Human CytokeRatin 18/KRT18 quantitates human Cytokeratin 18/KRT18 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Cytokeratin 18/KRT18.
Cytokeratin 18 (Keratin 18, KRT18, type I cytoskeletal 18) belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8. Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18. Further, cytokeratin 18 is found primarily in non-squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas, but not in squamous cell carcinomas. Hepatocellular carcinomas express only cytokeratins 8 and 18. Mutations in the cytokeratin 18 gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for the cytokeratin 18 gene. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.

Specifications
Specifications
Accession Number | cb83; Cell proliferation-inducing gene 46 protein; CK 18; CK18; CK-18; CYK18; cytokeratin 18; cytokeratin endo B; cytokeratin type -1; DAPK-1; Cytokeratin18; cytokeratin-18; dapk1; Dorsal aorta proneprin kinesin-1; DreK18; Endo B; I79 |
Assay Range | 0.164 to 40 ng/mL |
Assay Sensitivity | 0.164 ng/mL |
Conjugate | HRP |
Product Type | ELISA |
Sample Type | Plasma, Serum, Supernatant |
For Use With (Equipment) | Colorimetric Microplate Reader |
Gene ID (Entrez) | 3875 |
Gene Symbol | KRT18 |
Interassay CV | <12% |
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Safety and Handling
WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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