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Invitrogen™ Human DC-SIGN (ED) Synthetic Peptide

Catalog No. PEP0092
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50 μg
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PEP0092 50 μg
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Catalog No. PEP0092 Supplier Invitrogen™ Supplier No. PEP0092
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Description

Synthetic Peptide

DC-SIGN (ED) Synthetic Peptide, PEP-0092, from Invitrogen.

This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.
TRUSTED_SUSTAINABILITY

Specifications

Gene ID (Entrez) 30835
Species Human
Purification Method purified
Accession Number Q9NNX6
Common Name Human DC-SIGN (ED)
Concentration 200 μg/mL
Content And Storage -20°C
Description Synthetic Peptide
Format Liquid
Formulation PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
For Use With (Application) Blocking Assay, Control
Gene Symbol CD209
Lyophilized No
Preservative 0.02% sodium azide
Product Type Peptide
Quantity 50 μg
Regulatory Status RUO - research use only
Storage Buffer PBS
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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