Abnova™ Human FGFR1 (NM_000604.2, 456 a.a. - 765 a.a.) V561M mutant Partial Protein expressed in Sf9 cells

Catalog No.	Quantity
89-944-513	100 μg

Catalog No. 89-944-513 Supplier Abnova™ Supplier No. P4832

Description

Used for Func, SDS-PAGE

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq]

Specifications

• Accession Number: NM_000604.2
• Concentration: 0.140 ug/uL
• For Use With (Application): Functional Study, SDS-PAGE
• Formulation: Liquid
• Gene ID (Entrez): 2260
• Molecular Weight (g/mol): 35,899kDa
• Name: FGFR1 (V561M) (Human) Recombinant Protein
• Preparation Method: Insect cell (Sf9) expression system
• Purification Method: GST affinity chromatography
• Quality Control Testing: 2 ug/lane SDS-PAGE Stained with Coomassie Blue
• Quantity: 100 μg
• Storage Requirements: Store at -80°C. Aliquot to avoid repeated freezing and thawing
• Regulatory Status: RUO
• Gene Alias: BFGFR/CD331/CEK/FGFBR/FLG/FLJ99988/FLT2/HBGFR/KAL2/N-SAM
• Common Name: FGFR1
• Gene Symbol: FGFR1
• Biological Activity: 75pmol/μg x min
• Species: Baculovirus
• Protein Tag: None
• Expression System: Insect cell (Sf9) expression system
• Form: Liquid