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Abnova™ Human FGFR1 (NM_000604.2, 456 a.a. - 765 a.a.) V561M mutant Partial Protein expressed in Sf9 cells
Used for Func, SDS-PAGE
Supplier: Abnova™ P4832
Description
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq]
Specifications
NM_000604.2 | |
Functional Study, SDS-PAGE | |
2260 | |
FGFR1 (V561M) (Human) Recombinant Protein | |
GST affinity chromatography | |
100 ug | |
RUO | |
FGFR1 | |
75pmol/μg x min | |
None | |
Liquid |
0.140 ug/uL | |
Liquid | |
35,899kDa | |
Insect cell (Sf9) expression system | |
2 ug/lane SDS-PAGE Stained with Coomassie Blue | |
Store at -80°C. Aliquot to avoid repeated freezing and thawing | |
BFGFR/CD331/CEK/FGFBR/FLG/FLJ99988/FLT2/HBGFR/KAL2/N-SAM | |
FGFR1 | |
Baculovirus | |
Insect cell (Sf9) expression system |
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