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R&D Systems™ Recombinant Human GITR Ligand/TNFSF18 (CHO-expressed)

Catalog No. 6987GL025CF
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Formulation:
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Lyophilized from a 0.2 μm filtered solution in PBS.
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Catalog No. Formulation
6987GL025CF Lyophilized from a 0.2 μm filtered solution in PBS.
6987GL025 Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
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Catalog No. 6987GL025CF Supplier R&D Systems™ Supplier No. 6987GL025/CF
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Description

Extensive quality control produces industry leading bioactivity and lot-to-lot consistency that instills confidence in results and ensures reproducibility.

Measured by its ability to induce IL-8 secretion in HT1080 human fibrosarcoma cells transfected with GITR. Wyzgol, A. et al. (2009) J. Immunol. 183:1851. The ED50 for this effect is 4-20 ng/mL. The activity can be enhanced approximately 10-fold in the presence of Mouse Anti-Hemagglutinin/HA Peptide Monoclonal Antibody (Catalog # MAB060 ).

Specifications

Accession Number NP_005083
For Use With (Application) Bioactivity
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Gene ID (Entrez) 8995
Molecular Weight (g/mol) M.W. (Observed): 21-30 kDa, reducing conditions; M.W. (theoretical): 19.6 kDa (monomer)
Name GITR Ligand/TNFSF18
Quantity 25 μg
Source Chinese Hamster Ovary cell line, CHO-derived human GITR Ligand/TNFSF18 protein Hemagglutinin Tag (YPYDVPDYA) GCN4-IZ GGGSGGGSGGGS Human GITR Ligand (Glu74-Ser199) (N-terminus) Accession # NP_005083 (C-terminus)
Storage Requirements Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20°C to -70°C as supplied. 1 month, 2°C to 8°C under sterile conditions after reconstitution. 3 months, -20°C to -70°C under sterile conditions after reconstitution.
Structural Form Non-covalently-linked trimer
Endotoxin Concentration <0.10 EU / 1 μg of the protein by the LAL method.
Gene Alias Activation-inducible TNF-related ligand, AITRL, AITRLMGC138237, GITRL, GITRLglucocorticoid-induced TNFR-related protein ligand, Glucocorticoid-induced TNF-related ligand, hGITRLGITR ligand, TL6AITR ligand, TNFSF18, tumor necrosis factor (ligand) superfamily, member 18, tumor necrosis factor ligand superfamily member 18
Gene Symbol TNFSF18
Conjugate Unconjugated
Recombinant Recombinant
Reconstitution Reconstitute at 100 μg/mL in PBS.
Purity or Quality Grade >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie™ Blue Staining.
Protein GITR Ligand/TNFSF18
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