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R&D Systems™ Human Glucosylceramidase/GBA Recombinant Protein, Carrier-Free

Catalog No. 7410GH01M
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1 mg
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74-10G-H01M 1 mg
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Catalog No. 74-10G-H01M Supplier R&D Systems™ Supplier No. 7410GH01M
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Description

Defects in Glucosylceramidase are the cause of Gaucher disease, also known as glucocerebrosidase deficiency.

Glucosylceramidase is lysosomal enzyme that cleaves the beta-glucosidic linkage of glucosylceramide, an intermediate in glycolipid metabolism. The mature enzyme has 497 amino acids with a molecular weight of 62 kDa. Glycosylation occurs at four of five N-glycosylation sites and is essential for the trafficking and activity of the enzyme.

Storage:

Use manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, −70°C as supplied. 3 months, −70°C under sterile conditions after opening.

Order Info

Ships at ambient temperature.

Specifications

Accession Number P04062
Formulation Lyophilized from a 0.2μm filtered solution in Tris, NaCl, Glycerol and DTT
Gene ID (Entrez) 2629
Molecular Weight (g/mol) 56 kDa
Quantity 1 mg
Storage Requirements Use manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, −70°C as supplied. 3 months, −70°C under sterile conditions after opening.
Regulatory Status RUO
Endotoxin Concentration <1.0 EU per 1μg of the protein by the LAL method
Biological Activity >180pmol/min/μg
Product Type Recombinant protein
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Purity or Quality Grade >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie™ Blue Staining
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