Gibco™ Human GM-CSF Recombinant Protein, PeproTech®

E. coli Recombinant Protein

Supplier:  Gibco™ 3000320UG

Catalog No. 300-03-20UG

Description

GM-CSF (Granulocyte-Macrophage colony-stimulating factor) is a 14.6kDa hematopoietic growth factor that exists in glycosylated and non-glycosylated biologically active forms, and stimulates the development of granulocytes, macrophages, early megakaryocytes and eosinophil progenitor cells. The active form of the GM-CSF protein is found extracellularly as a homodimer and the GM-CSF gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q-syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. The ability of recombinant GM-CSF to increase hematopoietic cell recovery has become a focus area in the therapeutic treatment of patients following bone marrow transplantation. Recent studies have investigated GM-CSF in inflammatory and autoimmune diseases such as arthritis, arthritis related interstitial lung disease, nephritis, and psoriasis. In the CNS, GM-CSF depletion or neutralization has been studied in experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS).

Specifications

• Accession Number: P04141
• Format: Lyophilized
• Gene ID (Entrez): 1437
• Name: Human GM-CSF
• Quantity: 20 µg
• Storage Requirements: -20°C
• Endotoxin Concentration: <1 EU/µg
• Gene Symbol: CSF2
• Conjugate: Unlabeled
• Sequence: MAPARSPSPS TQPWEHVNAI QEARRLLNLS RDTAAEMNET VEVISEMFDL QEPTCLQTRL ELYKQGLRGS LTKLKGPLTM MASHYKQHCP PTPETSCATQ IITFESFKEN LKDFLLVIPF DCWEPVQE

• For Use With (Application): ELISA, Functional Assay, Western Blot
• Formulation: protein with no preservative
• Molecular Weight (g/mol): 14.6
• Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
• Source: E. coli
• Regulatory Status: RUO
• Gene Alias: colony stimulating factor 2; colony stimulating factor 2 (granulocyte-macrophage); colony-stimulating factor; CSF; CSF2; Csfgm; cytokine; GMCSF; Gm-CSf; granulocyte macrophage colony stimulating factor; granulocyte macrophage-colony stimulating factor; granulocyte-macrophage colony stimulating factor 2; granulocyte-macrophage colony-stimulating factor; MGC131935; MGC138897; MGC151255; MGC151257; MGI-IGM; M-GM-CSF; molgramostin; put. GM-CSF; sargramostim
• Specific Reactivity: Human
• Recombinant: Yes