Gibco™ Human Gremlin-1 Recombinant Protein, PeproTech®

Description

Recombinant Protein

120-42-1MG will be provided as 2 x 500 μg (120-42-500UG). Recombinant Human Gremlin-1 is a 18.3 kDa protein containing 160 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

In Xenopus, Gremlin belongs to a novel gene family that act as BMP antagonists in embryonic explants. The human homolog of Drm/Gremlin (CKTFS1B1) is localized on human chromosome 15q13-- q15. DRM-specific mRNA is expressed in different human tissues, including brain, ovary, intestine and colon. It has been suggested that down-regulation of DRM is associated with tumor progression, and support the hypothesis that human DRM may play an important role during both neuroembryological development and carcinogenesis.

Specifications

• Accession Number: O60565
• For Use With (Application): Functional Assay
• Formulation: protein with no preservative
• Gene ID (Entrez): 26585
• Molecular Weight (g/mol): 18.3 kDa
• Name: Human Gremlin-1
• Quantity: 500 μg
• Source: CHO cells
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/ μg
• Gene Alias: C15DUPq; Cell proliferation-inducing gene 2 protein; CKTSF1B1; colorectal adenoma and carcinoma 1; CRAC1; CRCS4; Cysteine knot superfamily 1, BMP antagonist 1; DAN domain family member 2; DAND2; Down-regulated in Mos-transformed cells protein; down-regulated in v-mos-transformed cells; Drm; DUP15q; Grem; GREM1; gremlin; gremlin 1; gremlin 1 homolog, cysteine knot superfamily; gremlin 1, cysteine knot superfamily, homolog; gremlin 1, DAN family BMP antagonist; gremlin 1-like protein; gremlin-1; HMPS; HMPS1; IHG-2; Increased in high glucose protein 2; increased in high glucose-2; ld; MPSH; PIG2
• Common Name: GREM1
• Gene Symbol: Grem1
• Biological Activity: Determined by its ability to inhibit BMP-4 induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 0.07-0.11 ug/ml
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: KKKGSQGAIP PPDKAQHNDS EQTQSPQQPG SRNRGRGQGR GTAMPGEEVL ESSQEALHVT ERKYLKRDWC KTQPLKQTIH EEGCNSRTII NRFCYGQCNS FYIPRHIRKE EGSFQSCSFC KPKKFTTMMV TLNCPELQPP TKKKRVTRVK QCRCISIDLD
• Content And Storage: -20°C
• Expression System: CHO cells
• Form: Lyophilized
• Purity or Quality Grade: ≥ 90% by SDS-PAGE gel and HPLC analyses.