Gibco™ Human IGF-BP2 Recombinant Protein, PeproTech®

Catalog No.	Quantity
35-006-B01M	2 x 500 μg
35006B100UG	100 μg
35006B20UG	20 μg
35006B250UG	250 μg
35006B500UG	500 μg
35006B50UG	50 μg
350-06B-5UG	5 μg

Catalog No. 35-006-B01M Supplier Gibco™ Supplier No. 35006B01M

Description

Recombinant Protein

350-06B-1MG will be provided as 2 x 500 μg (350-06B-500UG). Recombinant Human IGF-BP2 is a 31.5 kDa protein consisting of 289 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

IGFBP2 (insulin-like growth factor binding protein 2) is a member of the ISGBP family which bind various IGFs. IGFBP2 is overexpressed in a wide spectrum of cancers, including glioma, prostate cancer, synovial sarcoma, neuroblastoma, colon cancer, adrenocortical cancer, lung cancer, Wilms' tumor, and hepatoblastoma. The overexpression of IGFBP2 also correlates with the aggressiveness of some tumors. IGFBP2 activates the expression of matrix metalloprotease 2, which contributes to cell invasiveness.

Specifications

• Accession Number: P18065
• For Use With (Application): Functional Assay
• Formulation: protein with no preservative
• Gene ID (Entrez): 3485
• Molecular Weight (g/mol): 31.5 kDa
• Name: Human IGF-BP2
• Quantity: 2 x 500 μg
• Source: Insect cells
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/ μg
• Gene Alias: AI255832; BP2; BRL-BP; IBP2; IBP-2; IGF binding protein 2; IGF-binding protein 2; IGFBP; IGFBP2; IGFBP-2; IGF-BP53; ILGFBPA; Insulin like growth factor binding protein; insulin like growth factor binding protein 2; insulin-like growth factor binding protein 2; insulin-like growth factor binding protein 2, 36 kDa; insulin-like growth factor-binding protein 2; mIGFBP-2; OTTHUMP00000207753
• Common Name: IGFBP2
• Gene Symbol: IGFBP2
• Biological Activity: Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells.
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: EVLFRCPPCT PERLAACGPP PVAPPAAVAA VAGGARMPCA ELVREPGCGC CSVCARLEGE ACQVYTPRCG QGLRCYPHPG SELPLQALVM GEGTCEKRRD AEYGASPEQV ADNGDDHSEG GLVENHVDST MNMLGGGGSA GRKPLKSGMK ELAVFREKVT EQHRQMGKGG KHHLGLEEPK KLRPPPARTP CQQELDQVLE RISTMRLPDE RGPLEHLYSL HIPNCDKHGL YNLKQCKMSL NGQRGECWCV NPNTGKLIQG APTIRGDPEC HLFYNEQQEA RGVHTQRMQ
• Content And Storage: -20°C
• Expression System: Insect cells
• Form: Lyophilized
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.