Invitrogen™ Human IL-12 p40 Recombinant Protein

Catalog No.	Quantity
PIRP75619	1 mg

Catalog No. PIRP75619 Supplier Invitrogen™ Supplier No. RP75619

Description

Recombinant Protein

This product contains purified recombinant human IL-12 p40 protein with an N-terminal hexahistidine tag. This product may be used as a positive control in many immunological assays.

IL12B (IL-12 p40) encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kDa cytokine receptor like subunit encoded by this gene, and a 35 kDa subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.

Specifications

• Accession Number: P29460
• Concentration: 0.21 mg/mL
• For Use With (Application): Control, Western Blot
• Formulation: 25 mM sodium phosphate with 50% glycerol and no preservative; pH 7.0
• Gene ID (Entrez): 3593
• Molecular Weight (g/mol): 39.2 kDa
• Name: Human IL-12 p40
• Quantity: 1 mg
• Source: E. coli
• Immunogen: N/A
• Regulatory Status: RUO
• Gene Alias: CLMF; CLMF p35; CLMF p40; CLMF2; cytotoxic lymphocyte maturation factor 40 kDa subunit; il 12; Il12; IL12 p40; IL-12 p40 subunit; IL-12 subunit p35; IL-12 subunit p40; IL12, subunit p40; IL-12.p40; IL12A; IL-12 A; Il12b; IL-12 B; Il12p40; IL-12p40; IL-12p40 subunit; ILN; IMD28; IMD29; Interleukin; Interleukin 12; interleukin 12 p40 subunit; interleukin 12 subunit p40; interleukin 12, p40; interleukin 12 B; interleukin 12 B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); Interleukin12; interleukin-12 beta chain; interleukin-12 beta chain precursor; interleukin-12 p40; interleukin-12 p40 chain; interleukin-12 p40 subunit; interleukin-12 subunit beta; interleukin-12 subunit p40; interleukin-12p40; interleukin-23 p40 subunit; natural killer cell stimulatory factor, 40 kD subunit; NK cell stimulatory factor chain 2; NKSF; NKSF1; NKSF2; p40; RP23-388G23.1
• Common Name: IL-12 p40
• Gene Symbol: IL12B
• Conjugate: Unconjugated
• Species: E. coli
• Recombinant: Recombinant
• Protein Tag: His-tag
• Sequence: Amino acids Ile23- Ser328 containing an N-terminal His-tag
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Protein Subtype: Recombinant
• Purity or Quality Grade: >95%, by SDS-PAGE under reducing conditions