Gibco™ Human IL-12 p80 Recombinant Protein, PeproTech®

Insect cells Recombinant Protein

Supplier:  Gibco™ 20012P80H100UG

Catalog No. 20012P80H1

Description

IL-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicates that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23, or it can form the homodimer designated IL-12 p80. Elevated levels of IL-12 p80 correlate to macrophage recruitment and increased inflammation in asthma and respiratory viral infection models.

Specifications

• Accession Number: P29460
• Format: Lyophilized
• Gene ID (Entrez): 3593
• Name: Human IL-12 p80
• Quantity: 100 µg
• Storage Requirements: -20°C
• Endotoxin Concentration: <1 EU/µg
• Gene Symbol: IL12B
• Conjugate: Unlabeled
• Sequence: p40 subunit: IWELKKDVYV VELDWYPDAP GEMVVLTCDT PEEDGITWTL DQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGEVLSHSLL LLHKKEDGIW STDILKDQKE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDPQGVTCGA ATLSAERVRG DNKEYEYSVE CQEDSACPAA EESLPIEVMV DAVHKLKYEN YTSSFFIRDI IKPDPPKNLQ LKPLKNSRQV EVSWEYPDTW STPHSYFSLT FCVQVQGKSK REKKDRVFTD KTSATVICRK NASISVRAQD RYYSSSWSEW ASVPCS

• For Use With (Application): Functional Assay
• Formulation: protein with no preservative
• Molecular Weight (g/mol): 80
• Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.
• Source: Insect cells
• Regulatory Status: RUO
• Gene Alias: IL-12
• Specific Reactivity: Human
• Recombinant: Yes