Gibco™ Human IL-21 Recombinant Protein, PeproTech®

E. coli Recombinant Protein

Supplier:  Gibco™ 2002110UG

Catalog No. 200-21-10UG

Description

IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by Natural Killer Cells (NKT), T helper (Th) 17 and T follicular helper (TFH) cells. In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which leads to additional transcriptional activation by Bcl6. As with IFN gamma for Th1 and IL-4 for Th2 cells, IL-21 is critical for TFH cell development and effector function. IL-21 plays a role in T cell-dependent B cell differentiation into plasma cells and memory cells, stimulation of IgG production and induction of apoptotic signaling in naive B cells. In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4 and ROR gamma t lead to upregulation of the IL-23R, thereby preparing Th17 cells for maturation and maintenance by the inflammatory cytokine IL-23. While upregulating IRF4 and ROR gamma t, IL-21 also mediates the downregulation of Foxp3. IL-21 deficient mice are protected from developing colitis upon chemical treatment by their inability to upregulate Th17-associated molecules. In comparison, elevated levels of IL-21 are present in chemically-induced colitis mouse models.

Specifications

• Accession Number: Q9HBE4
• Format: Lyophilized
• Gene ID (Entrez): 59067
• Name: Human IL-21
• Quantity: 10 µg
• Storage Requirements: -20°C
• Endotoxin Concentration: <1 EU/µg
• Gene Symbol: IL21
• Conjugate: Unlabeled
• Sequence: MQDRHMIRMR QLIDIVDQLK NYVNDLVPEF LPAPEDVETN CEWSAFSCFQ KAQLKSANTG NNERIINVSI KKLKRKPPST NAGRRQKHRL TCPSCDSYEK KPPKEFLERF KSLLQKMIHQ HLSSRTHGSE DS

• For Use With (Application): ELISA, Functional Assay, Western Blot
• Formulation: protein with no preservative
• Molecular Weight (g/mol): 15.4
• Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
• Source: E. coli
• Regulatory Status: RUO
• Gene Alias: CVID11; C x 2; il 21; IL21; IL-21; ILN; Interleukin; interleukin 21; Interleukin21; interleukin-21; interleukin-21 isoform; porcine interleukin-21; Za11
• Specific Reactivity: Human
• Recombinant: Yes