Gibco™ Human IL-35 Recombinant Protein, PeproTech®

Catalog No.	Quantity
20037100UG	2 x 50 μg
200-37-10UG	10 μg
200-37-2UG	2 μg
200-37-50UG	50 μg

Catalog No. 20037100UG Supplier Gibco™ Supplier No. 20037100UG

Description

Recombinant Protein

200-37-100UG will be provided as 2 x 50 μg (200-37-50UG). 200-37-1MG will be provided as 20 x 50 μg (200-37-50UG). 200-37-250UG will be provided as 5 x 50 μg (200-37-50UG). 200-37-500UG will be provided as 5 x 100 μg (200-37-50UG). Recombinant Recombinant Human IL-35 expressed in HEK293 cells contains 406 amino acid residues and has a calculated molecular weight of 45.8 kDa. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

IL-35, or Interleukin 35 is a cytokine belonging to the IL12 family, that is produced by regulatory T cells. It is a dimeric protein composed of IL-12-alpha and IL-27-beta chains. Members of this class of cytokines are important in influencing T helper cell differentiation and supressing inflammatory response. IL-35 is known to induce proliferation of regulatory T cells, and reduce the activity of helper Th17 cells.

Specifications

• Accession Number: P29459
• For Use With (Application): Functional Assay
• Formulation: protein with no preservative
• Gene ID (Entrez): 3592
• Molecular Weight (g/mol): 45.8 kDa
• Name: Human IL-35
• Quantity: 2 x 50 μg
• Source: HEK293 cells
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/ μg
• Gene Alias: CLMF; CLMF p35; cytokine receptor; cytotoxic lymphocyte maturation factor 1, p35; cytotoxic lymphocyte maturation factor 35 kDa subunit; EBI3; EBV-induced gene 3 protein; Epstein-Barr virus induced 3; Epstein-Barr virus induced gene 3; epstein-Barr virus-induced gene 3 protein; IL-12 subunit p35; IL-12, subunit p35; IL12A; IL-12 A; IL12p35; IL27 subunit; IL-27 subunit beta; IL27B; IL-27 B; il35; IL35 subunit; ILN; Interleukin; interleukin 12, p35; interleukin 12 A; interleukin 12 A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); interleukin-12 alpha chain; interleukin-12 subunit alpha; Interleukin-27 subunit beta; Interleukin-35; NF cell stimulatory factor chain 1; NFSK; NK cell stimulatory factor chain 1; NKSF1; P35
• Common Name: IL-35
• Gene Symbol: IL12A
• Biological Activity: Measured by its ability to inhibit proliferative activity of PBMCs.
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: Alpha Subunit: RNLPVATPDP GMFPCLHHSQ NLLRAVSNML QKARQTLEFY PCTSEEIDHE DITKDKTSTV EACLPLELTK NESCLNSRET SFITNGSCLA SRKTSFMMAL CLSSIYEDLK MYQVEFKTMN AKLLMDPKRQ IFLDQNMLAV IDELMQALNF NSETVPQKSS LEEPDFYKTK IKLCILLHAF RIRAVTIDRV MSYLNAS Beta Subunit: RKGPPAALTL PRVQCRASRY PIAVDCSWTL PPAPNSTSPV SFIATYRLGM AARGHSWPCL QQTPTSTSCT ITDVQLFSMA PYVLNVTAVH PWGSSSSFVP FITEHIIKPD PPEGVRLSPL AERQLQVQWE PPGSWPFPEI FSLKYWIRYK RQGAARFHRV GPIEATSFIL RAVRPRARYY VQVAAQDLTD YGELSDWSLP ATATMSLGK
• Content And Storage: -20°C
• Expression System: HEK293 cells
• Form: Lyophilized
• Purity or Quality Grade: ≥ 90% by SDS-PAGE gel and HPLC analyses.