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Abnova™ Human IL12A (P29459, 503 amino acids) Partial Recombinant Protein expressed in CHO cells

Used for Func, SDS-PAGE

Manufacturer:  Abnova™ P3997

Catalog No. 89-948-620


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Description

Description

This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq]

Specifications

Specifications

P29459
Functional Study, Sodium Dodecyl Sulfate–Polyacrylamide Gel Electrophoresis
Lyophilized
75kDa
Mammalian cell (CHO) expression system
10 ug
RUO
CLMF|IL-12A|NFSK|NKSF1|P35
IL12A
Hamster
None
Mammalian cell (CHO) expression system
Lyophilized
3592
IL12A (Human) Recombinant Protein
≥98% by SDS-PAGE and HPLC
Store at -20°C on dry atmosphere. After reconstitution with PBS, store at 4°C for 1 week or -20°C for longer. Aliquot to avoid repeated freezing and thawing.
<0.1ng/μg
IL12A
The ED50 was determined by the induction of IFN-g production from murine splenocytes co-stimulated with IL-12 is < 0.1ng/mL, corresponding to a specific activity of > 1 x 107 units/mg.
Yes
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