Abnova™ Human IL12A (P29459, 503 amino acids) Partial Recombinant Protein expressed in CHO cells

Catalog No.	Quantity
89-948-620	10 μg

Catalog No. 89-948-620 Supplier Abnova™ Supplier No. P3997

Description

Used for Func, SDS-PAGE

This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq]

Specifications

• Accession Number: P29459
• For Use With (Application): Functional Study, SDS-PAGE
• Formulation: Lyophilized
• Gene ID (Entrez): 3592
• Molecular Weight (g/mol): 75kDa
• Name: IL12A (Human) Recombinant Protein
• Preparation Method: Mammalian cell (CHO) expression system
• Quantity: 10 μg
• Storage Requirements: Store at -20°C on dry atmosphere. After reconstitution with PBS, store at 4°C for 1 week or -20°C for longer. Aliquot to avoid repeated freezing and thawing.
• Regulatory Status: RUO
• Endotoxin Concentration: <0.1ng/μg
• Gene Alias: CLMF/IL-12A/NFSK/NKSF1/P35
• Common Name: IL12A
• Gene Symbol: IL12A
• Biological Activity: The ED50 was determined by the induction of IFN-g production from murine splenocytes co-stimulated with IL-12 is < 0.1ng/mL, corresponding to a specific activity of > 1 x 10⁷ units/mg.
• Species: Human
• Recombinant: Recombinant
• Protein Tag: None
• Expression System: Mammalian cell (CHO) expression system
• Form: Lyophilized
• Purity or Quality Grade: ≥98% by SDS-PAGE and HPLC