Invitrogen™ Human INHA Recombinant Protein

Description

Recombinant Protein

RP-75632 contains a purified 134 amino acid fragment (aa233-366) corresponding to the mature Inhibin alpha subunit protein with an N-terminal hexahistidine tag. RP-75632 may be used as a positive control in Western blot assays.

The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone.

Specifications

• Accession Number: P05111
• Concentration: 0.05 mg/mL
• For Use With (Application): Control, Western Blot
• Formulation: Laemmli with no preservative; pH 6.8
• Gene ID (Entrez): 3623
• Molecular Weight (g/mol): 19.2 kDa
• Name: Human INHA
• pH Range: 6.8
• Quantity: 10 μg
• Source: E. coli
• Regulatory Status: RUO
• Gene Alias: A inhibin subunit; A-inhibin subunit; AW555078; IHA; Inha; inhibin; inhibin alpha; inhibin alpha chain; inhibin alpha subunit
• Common Name: INHA
• Gene Symbol: INHA
• Conjugate: Unconjugated
• Species: E. coli
• Recombinant: Recombinant
• Protein Tag: His-tag
• Sequence: Amino acids Ser233- Ile366 containing an N-terminal His-tag
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Protein Subtype: Recombinant
• Purity or Quality Grade: >95%, by SDS-PAGE under reducing conditions