Invitrogen™ Human KCNMA1 (aa 887-902) Synthetic Peptide

Description

Synthetic Peptide

Human Maxi K+ alpha (residues 887-902) Synthetic Peptide, PEP-122, from Invitrogen.

Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.

Specifications

• Gene ID (Entrez): 3778
• Species: Human
• Purification Method: purified
• Accession Number: Q12791
• Common Name: Human KCNMA1 (aa 887-902)
• Concentration: 0.5 mg/mL
• Content And Storage: -20°C. Avoid freeze-thaw cycles.
• Description: Synthetic Peptide
• Format: Lyophilized
• Formulation: peptide with no preservative
• For Use With (Application): Control
• Gene Symbol: KCNMA1
• Lyophilized: Lyophilized
• Preservative: No preservative
• Product Type: Peptide
• Quantity: 50 μg
• Regulatory Status: RUO - research use only
• Sequence: Derived from Amino Acids 887-902 of Human Maxi K+ a Protein

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov