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Invitrogen™ Human KCNMA1 (aa 887-902) Synthetic Peptide
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Quantity:
50 μg
Description
Human Maxi K+ alpha (residues 887-902) Synthetic Peptide, PEP-122, from Invitrogen.
Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.

Specifications
Specifications
Gene ID (Entrez) | 3778 |
Species | Human |
Purification Method | purified |
Accession Number | Q12791 |
Common Name | Human KCNMA1 (aa 887-902) |
Concentration | 0.5 mg/mL |
Content And Storage | -20°C. Avoid freeze-thaw cycles. |
Description | Synthetic Peptide |
Format | Lyophilized |
Formulation | peptide with no preservative |
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Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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