Gibco™ Human LD78 beta (CCL3L1) Recombinant Protein, PeproTech®

Catalog No.	Quantity
300-56-20UG	20 μg
30056100UG	100 μg
30056250UG	250 μg
30056500UG	500 μg
300-56-5UG	5 μg

Catalog No. 300-56-20UG Supplier Gibco™ Supplier No. 3005620UG

Description

Recombinant Protein

Recombinant Human LD78beta is a 7.7 kDa protein containing 70 amino acid residues, including the four conserved cysteine residues present in CC chemokines. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility. This record represents one of two copies that are present on the ALT_REF_LOCI_2 alternate haplotype of the GRCh38 human reference genome assembly. Alternative splicing of this gene results in multiple transcript variants.

Specifications

• Accession Number: P16619
• For Use With (Application): ELISA, Functional Assay, Western Blot
• Formulation: protein with no preservative
• Gene ID (Entrez): 6349
• Molecular Weight (g/mol): 7.7 kDa
• Name: Human LD78 beta (CCL3L1)
• Quantity: 20 μg
• Source: E. coli
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/ μg
• Gene Alias: 464.2; C-C motif chemokine 3-like 1; C-C motif chemokine ligand 3 like 1; CC-chemokine (CCL3); MIP1a; CCL3L1; CCL3L3; chemokine (C-C motif) ligand 3-like 1; chemokine ligand 3-like 1; D17S1718; G0/G1 switch regulatory protein 19-2; G0S19-2; LD78; LD78BETA; LD78-beta(1-70); LD78-beta(3-70); LD78-beta(5-70); macrophage inflamatory protein 1 alpha; MIP1AP; PAT 464.2; SCYA3L; SCYA3L1; small inducible cytokine A3-like 1; Small-inducible cytokine A3-like 1; Tonsillar lymphocyte LD78 beta protein
• Common Name: CCL3L1
• Gene Symbol: CCL3L1
• Biological Activity: Determined by its ability to chemoattract mouse BaF3 cells expressing the CCR5 receptor using a concentration range of 5.0-25.0 ng/ml
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: APLAADTPTA CCFSYTSRQI PQNFIADYFE TSSQCSKPSV IFLTKRGRQV CADPSEEWVQ KYVSDLELSA
• Content And Storage: -20°C
• Expression System: E. coli
• Form: Lyophilized
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.