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ACROBiosystems Human LILRB4 2Vials

Supplier:  ACROBiosystems CHEKATP0882VIALS

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Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K) Immunoglobulin-like transcript 3 (ILT-3) Leukocyte immunoglobulin-like receptor 5 (LIR-5) Monocyte inhibitory receptor HM18 which belongs to the leukocyte immunoglobulin-like receptor (LIR) family. LILRB4 / CD85K contains 2 Ig-like C2-type (immunoglobulin-like) domains. CD85K is detected in monocytes macrophages dendritic cells lung natural killer cells and B-cells. LILRB4 / CD85K is receptor for class I MHC antigens. CD85K recognizes a broad spectrum of HLA-A HLA-B HLA-C and HLA-G alleles involved in the down-regulation of the immune response and the development of tolerance. LILRB4 interferes with TNFRSF5-signaling and NF-kappa-B up-regulation and inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Catalog No. 50-253-5282


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