R&D Systems™ Human LOXL1 (AAH68542) VersaClone cDNA

Catalog No.	Quantity
RDC2730	10 μg

Catalog No. RDC2730 Supplier R&D Systems™ Supplier No. RDC2730

Description

This shuttle vector contains the complete ORF for the gene of interest, along with a Kozak consensus sequence for optimal translation initiation. It is inserted NotI to AscI. The gene insert is flanked with convenient multiple cloning sites which can be used to easily cut and transfer the gene cassette into your desired expression vector.

• Also known as: LOL; LOXL
• LOXL1 is a member of the lysyl oxidase family of proteins.
• It is essential to the biogenesis of connective tissue.
• It is an extracellular copper-dependent amine oxidase that catalyzes the first step in the formation of crosslinks in collagen and elastin.
• A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function.
• The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.
• Mutations in LOXL1 are associated with exfoliation syndrome.
• The insert is sequence verified and the entire plasmid DNA and insert translated sequences are provided.
• For reasearch use only. Not for use in humans.

Specifications

• Gene: hLOXL1
• Accession Number: AAH68542
• Concentration: 10 μg at 0.2 μg/μL
• Formulation: cDNA is provided in 10 mM Tris-Cl, pH 8.5
• Insert Type: 1738 bp
• Gene ID (Entrez): 4016
• Content And Storage: Store the unopened product at -20°C to -70°C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
• Species: Human
• Quantity: 10 μg