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ACROBiosystems Human LRRC15 2Vials
Supplier: ACROBiosystems CHEKATP1232VIALS
LRRC15 (Leucine-rich repeat-containing protein 15) is also known as LIB and hLib. LRRC15 is highly expressed in a variety of solid tumors. LRRC15 was expressed on stromal fibroblasts in many solid tumors (e.g. breast head and neck lung pancreatic) as well as directly on a subset of cancer cells of mesenchymal origin (e.g. sarcoma melanoma glioblastoma). LRRC15 expression was induced by TGFβ on activated fibroblasts (αSMA+) and on mesenchymal stem cells. These collective findings suggested LRRC15 as a novel CAF and mesenchymal marker with utility as a therapeutic target for the treatment of cancers with LRRC15-positive stromal desmoplasia or cancers of mesenchymal origin. ABBV-085 is a monomethyl auristatin E (MMAE)-containing antibody–drug conjugate (ADC) directed against LRRC15 and it demonstrated robust preclinical efficacy against LRRC15 stromal-positive/cancer-negative and LRRC15 cancer-positive models as a monotherapy or in combination with standard-of-care therapies.
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