Gibco™ Human MANF Recombinant Protein, PeproTech®

E. coli Recombinant Protein

Supplier:  Gibco™ 45006100UG

Catalog No. 45006100UG

Description

The protein encoded by this gene is localized in the endoplasmic reticulum and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related.

Specifications

• Accession Number: P55145
• Formulation: protein with no preservative
• Molecular Weight (g/mol): 18.1
• Quantity: 100 μg
• Storage Requirements: -20°C
• Endotoxin Concentration: <1 EU/μg
• Gene Symbol: MANF
• Conjugate: Unconjugated
• Sequence: LRPGDCEVCI SYLGRFYQDL KDRDVTFSPA TIENELIKFC REARGKENRL CYYIGATDDA ATKIINEVSK PLAHHIPVEK ICEKLKKKDS QICELKYDKQ IDLSTVDLKK LRVKELKKIL DDWGETCKGC AEKSDYIRKI NELMPKYAPK AASARTDL
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.

• For Use With (Application): Functional Assay
• Gene ID (Entrez): 7873
• Name: Human MANF
• Source: E. coli
• Regulatory Status: RUO
• Gene Alias: 3230402M22Rik; AA407711; AA408789; AA673178; Arginine-rich protein; arginine-rich, mutated in early stage tumors; ARMET; ARP; D17914; D18Mgi17; Manf; mesencephalic astrocyte derived neurotrophic factor; mesencephalic astrocyte-derived neurotrophic factor; MGC142148; MGC142150; Protein ARMET
• Specific Reactivity: Human
• Recombinant: Recombinant
• Form: Lyophilized