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Gibco™ Human MANF Recombinant Protein, PeproTech®

Catalog No. 450065UG
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Catalog No. Quantity
450-06-5UG 5 μg
45006100UG 100 μg
450-06-1MG 1 mg
45006250UG 250 μg
450-06-25UG 25 μg
45006500UG 500 μg
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Catalog No. 450-06-5UG Supplier Gibco™ Supplier No. 450065UG
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Description

Recombinant Protein

Recombinant Human MANF is an 18.1 kDa protein consisting of 158 amino acids, including 8 cysteine residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

The protein encoded by this gene is localized in the endoplasmic reticulum and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P55145
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 7873
Molecular Weight (g/mol) 18.1 kDa
Name Human MANF
Quantity 5 μg
Source E. coli
Regulatory Status RUO
Endotoxin Concentration <1 EU/ μg
Gene Alias 3230402M22Rik; AA407711; AA408789; AA673178; Arginine-rich protein; arginine-rich, mutated in early stage tumors; ARMET; ARP; D17914; D18Mgi17; Manf; mesencephalic astrocyte derived neurotrophic factor; mesencephalic astrocyte-derived neurotrophic factor; MGC142148; MGC142150; Protein ARMET
Common Name ARMET
Gene Symbol MANF
Biological Activity Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 15-25 ug/ml
Conjugate Unconjugated
Recombinant Recombinant
Sequence LRPGDCEVCI SYLGRFYQDL KDRDVTFSPA TIENELIKFC REARGKENRL CYYIGATDDA ATKIINEVSK PLAHHIPVEK ICEKLKKKDS QICELKYDKQ IDLSTVDLKK LRVKELKKIL DDWGETCKGC AEKSDYIRKI NELMPKYAPK AASARTDL
Content And Storage -20°C
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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