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Invitrogen™ Human MDR1 Vesicles

Catalog No. GM0015
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GM0015 0.5 mL
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Catalog No. GM0015 Supplier Invitrogen™ Supplier No. GM0015
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Description

Human MDR1 Vesicles are insect derived purified plasma membranes with inserted MDR1 transport protein (P-glycoprotein, ABCB1). Our Human MDR1 Vesicles can be used to evaluate test compounds and drug interactions with MDR1 in in vitro assays.

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Specifications

Physical Form Frozen
Quantity 0.5 mL
Purity Research Grade
Host Species Human
Product Type Human Vesicle
Content And Storage Store at -80°C.
Format Vial
Shipping Condition Dry Ice

Frequently Asked Questions (FAQs)

What is the supplied quantity of ATP-binding cassette (ABC) Transporter Vesicles?

The quantity supplied is 2.5 mg total protein/500 µL per vial. The protein concentration is 5 mg/mL. When our recommended protocol is followed, 50 vesicular transport assays or 125 ATPase assays can be performed with one vial of ABC Transporter Vesicles product.
What is the storage condition for ATP-binding cassette (ABC) Transporter Vesicles?

We recommend storing them at -80 degrees C.
What are ATP-binding cassette (ABC) Transporter Vesicles?

Prepared from Sf9 cells which have been engineered to over-express specific ABC transporters, ATP-binding cassette (ABC) Transporter Vesicles are “inside-out” vesicles designed for use in vesicular transport assays. They allow the investigation of possible interactions between specific ABC transporters and test compounds. ABC Transporter Vesicles provide high levels of transporter activity with low background, giving a clear signal if the test compound is a substrate or inhibitor of a specific efflux transporter.

While ABC transporters typically mediate the efflux of substrates from cells, transporters expressed on these inside-out vesicles import substrates into the vesicles. It is therefore possible to quantitatively evaluate transport activity for the test compound by determining the amount incorporated into the vesicles.
Note: One vial of vesicle product can perform 50 vesicular transport assays.

For Research Use Only. Not for use in diagnostic procedures.

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