Gibco™ Human/Mouse/Rat Activin A Recombinant Protein, PeproTech®

Catalog No.	Quantity
12014100UG	100 μg
120-14-10UG	10 μg
12-014-01M	2 x 500 μg
12014250UG	250 μg
120-14-2UG	2 μg
12014500UG	500 μg
120-14-50UG	50 μg

Catalog No. 12014100UG Supplier Gibco™ Supplier No. 12014100UG

Description

Recombinant Protein

120-14-1MG will be provided as 2 x 500 μg (120-14-500UG). Recombinant Human/Murine/Rat Activin A is a 26.0 kDa disulfide-linked homodimer of two betaA chains, each containing 116 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Activin A mutations are associated with fibrodysplasia ossificans progressive.

Specifications

• Accession Number: P08476, P18331, Q04998
• For Use With (Application): Control, Bioactivity
• Formulation: Protein with no preservative
• Gene ID (Entrez): 16323, 29200, 3624
• Molecular Weight (g/mol): 26 kDa
• Name: Human/Mouse/Rat Activin A
• Purification Method: Purified
• Quantity: 100 μg
• Source: Insect cells
• Storage Requirements: -20°C
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/μg
• Gene Alias: activin A; activin beta-A chain; BMP7; BMP-7; Bone morphogenetic protein 7; EDF; Eptotermin alfa; erythroid differentiation factor; erythroid differentiation protein; follicle-stimulating hormone-releasing protein; FRP; FSH-releasing protein; INHB; Inhba; inhibin B subunit; inhibin beta A chain; inhibin beta A protein; inhibin beta A subunit; inhibin beta-A; inhibin beta-A-subunit; inhibin beta-subunit; inhibin subunit beta A; inhibin, beta A; inhibin, beta A (activin A, activin AB alpha polypeptide); Inhibin, beta-1; OP1; OP-1; Osteogenic protein 1; unnamed protein product
• Common Name: Activin A
• Gene Symbol: Inhba
• Biological Activity: Determined by its ability to inhibit the proliferation of mouse MPC-11 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg
• Product Type: Protein
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS
• Content And Storage: -20°C
• Activity: Determined by its ability to inhibit the proliferation of mouse MPC-11 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg.
• Expression System: Insect cells
• Form: Lyophilized
• Purity or Quality Grade: ≥ 95% by SDS-PAGE gel and HPLC analyses.