Gibco™ Human NNT-1/BCSF-3 Recombinant Protein, PeproTech®

Catalog No.	Quantity
450-18-1MG	1 mg
45018100UG	100 μg
450-18-10UG	10 μg
45018250UG	250 μg
450-18-2UG	2 μg
45018500UG	500 μg

Catalog No. 450-18-1MG Supplier Gibco™ Supplier No. 450181MG

Description

Recombinant Protein

Recombinant Human NNT-1/BCSF-3 is a 22.4 kDa protein containing 199 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

NNT-1/BCSF-3 is a neurotrophic factor with B-cell-stimulating capabilities. Expressed in the lymph nodes and spleen, NNT-1/BCSF-3 activates glycoprotein 130 (gp130) and leukemia inhibitory factor receptor member b (LIFR-b) by binding and inducing the tyrosine phosphorylation of these receptors. In vitro, it supports the survival of chick embryo motor and sympathetic neurons. In mice, NNT-1/BCSF-3 induces serum amyloid A, causes body weight loss, and B cell hyperplasia associated with increases in serum IgG and IgM.

Specifications

• Accession Number: Q9UBD9
• For Use With (Application): ELISA, Functional Assay, Western Blot
• Formulation: protein with no preservative
• Gene ID (Entrez): 23529
• Molecular Weight (g/mol): 22.4 kDa
• Name: Human NNT-1/BCSF-3
• Quantity: 1 mg
• Source: E. coli
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/ μg
• Gene Alias: b cell-stimulating factor 3; B-cell stimulating factor 3; B-cell stimulatory factor 3; B-cell-stimulating factor 3; Bsf3; BSF-3; Cardiotrophin-like cytokine factor 1; CISS2; Clc; CLCF1; CRLF1 associated cytokine-like factor 1; neurotrophin-1/B-cell stimulating factor-3; NNT1; NNT-1; NNT-1/BSF-3; Novel neurotrophin-1; NR6
• Common Name: NNT1
• Gene Symbol: CLCF1
• Biological Activity: NT-1/BCSF-3 weakly supports chick E8 DRG neurite outgrowth (at a concentration of 1.0 ng/ml)
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: MLNRTGDPGP GPSIQKTYDL TRYLEHQLRS LAGTYLNYLG PPFNEPDFNP PRLGAETLPR ATVDLEVWRS LNDKLRLTQN YEAYSHLLCY LRGLNRQAAT AELRRSLAHF CTSLQGLLGS IAGVMAALGY PLPQPLPGTE PTWTPGPAHS DFLQKMDDFW LLKELQTWLW RSAKDFNRLK KKMQPPAAAV TLHLGAHGF
• Content And Storage: -20°C
• Expression System: E. coli
• Form: Lyophilized
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.