Gibco™ Human Oncostatin M (209 aa) Recombinant Protein, PeproTech®

Catalog No.	Quantity
30010T500UG	500 μg
30010T100UG	100 μg
30010T10UG	10 μg
300-10T-1MG	1 mg
30010T250UG	250 μg
300-10T-2UG	2 μg
30010T50UG	50 μg

Catalog No. 30010T500UG Supplier Gibco™ Supplier No. 30010T500UG

Description

Recombinant Protein

Recombinant Human Oncostatin M is a 23.6 kDa protein, containing 209 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi's sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi's sarcoma cells, but inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells. OSM shares several structural and functional characteristics with LIF, IL-6, and CNTF.

Specifications

• Accession Number: P13725
• For Use With (Application): Functional Assay
• Formulation: protein with no preservative
• Gene ID (Entrez): 5008
• Molecular Weight (g/mol): 23.6 kDa
• Name: Human Oncostatin M (209 aa)
• Quantity: 500 μg
• Source: E. coli
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/ μg
• Gene Alias: MGC20461; OncoM; oncostatin M; oncostatin-M; OSM
• Common Name: Oncostatin M
• Gene Symbol: OSM
• Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: AAIGSCSKEY RVLLGQLQKQ TDLMQDTSRL LDPYIRIQGL DVPKLREHCR ERPGAFPSEE TLRGLGRRGF LQTLNATLGC VLHRLADLEQ RLPKAQDLER SGLNIEDLEK LQMARPNILG LRNNIYCMAQ LLDNSDTAEP TKAGRGASQP PTPTPASDAF QRKLEGCRFL HGYHRFMHSV GRVFSKWGES PNRSRRHSPH QALRKGVRR
• Content And Storage: -20°C
• Expression System: E. coli
• Form: Lyophilized
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.