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ACROBiosystems Biotinylated Human Oncostatin M, Avitag,His Tag (OSM-H82Q8) is expressed from human 293 cells (HEK293). It contains AA Ala 26 - Arg 221 (Accession # P13725-1).
Supplier: ACROBiosystems OSMH82Q825UG
Oncostatin M is also known as OSM, is a glycoprotein belonging to the interleukin-6 family of cytokines that has functions mainly in cell growth. Of these cytokines it most closely resembles leukemia inhibitory factor (LIF) in both structure and function. However, it is as yet poorly defined and is proving important in liver development, haematopoeisis, inflammation and possibly CNS development. It is also associated with bone formation and destruction. OSM signals through cell surface receptors that contain the protein gp130. The type I receptor is composed of gp130 and LIFR, the type II receptor is composed of gp130 and OSMR. Oncostatin M (OSM) was previoustly identified by its ability to inhibit the growth of cells from melanoma and other solid tumors.
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