Abnova™ Human PRKCI (NM_002740) Full-length Recombinant Protein expressed in Sf9 cells

Catalog No.	Quantity
89-958-184	5 μg

Catalog No. 89-958-184 Supplier Abnova™ Supplier No. P4189

Description

Used for Func, SDS-PAGE

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq]

Specifications

• Accession Number: NM_002740
• For Use With (Application): Functional Study, SDS-PAGE
• Formulation: Liquid
• Gene ID (Entrez): 5584
• Molecular Weight (g/mol): 98kDa
• Name: PRKCI (Human) Recombinant Protein
• Quantity: 5 μg
• Storage Requirements: Store at -80°C. Aliquot to avoid repeated freezing and thawing.
• Regulatory Status: RUO
• Gene Alias: DXS1179E/MGC26534/PKCI/nPKC-iota
• Common Name: PRKCI
• Gene Symbol: PRKCI
• Biological Activity: 664nmol phosphate incorporated into CREBtide per minute per mg protein at 30°C for 15 minutes using a final concentration of 50μM ATP (0.83 uCi/assay in 25μL reaction volume).
• Species: Baculovirus
• Recombinant: Recombinant
• Protein Tag: None
• Form: Liquid
• Purity or Quality Grade: ≥90% by SDS-PAGE