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Invitrogen™ Human RANKL (Soluble) ELISA Kit

Catalog No. EEL071
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Quantity:
96 Tests

ELISA

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number O14788
Assay Range 15.63 to 1000 pg/mL
Assay Sensitivity 9.38 pg/mL
Conjugate HRP
Product Type ELISA
Sample Type Plasma, Serum
For Use With (Equipment) Colorimetric Microplate Reader
Gene ID (Entrez) 8600
Gene Symbol TNFSF11
Interassay CV <10%
Intraassay CV <10
Kit Contents Pre-coated 96 well plate, Standard, Biotinylated Detection Antibody, HRP Conjugate, Standard & Sample Diluent, Biotinylated Detection Antibody Diluent, HRP Conjugate Diluent, Wash Buffer, TMB Substrate, Stop Solution, Plate Sealer
Label or Dye HRP
Quantity 96 Tests
Regulatory Status RUO
Sample Volume Plasma 100 μL, Serum 100 μL
Storage Requirements Refer to product documentation for component specific storage temperature.
Target RANKL (RANK Ligand)
Test Time 1 hrs 20 mins
Total Assay Time 3 hrs 30 mins
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