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Invitrogen™ Human RANKL (Soluble) ELISA Kit

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Quantity:
96 Tests
Description
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.

Specifications
Specifications
Accession Number | O14788 |
Assay Range | 15.63 to 1000 pg/mL |
Assay Sensitivity | 9.38 pg/mL |
Conjugate | HRP |
Product Type | ELISA |
Sample Type | Plasma, Serum |
For Use With (Equipment) | Colorimetric Microplate Reader |
Gene ID (Entrez) | 8600 |
Gene Symbol | TNFSF11 |
Interassay CV | <10% |
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