Gibco™ Human/Rat Neuritin Recombinant Protein, PeproTech®

Catalog No.	Quantity
450-36D-5UG	5 μg
45036D100UG	100 μg
450-36D-1MG	1 mg
45036D20UG	20 μg
45036D250UG	250 μg
45036D500UG	500 μg

Catalog No. 450-36D-5UG Supplier Gibco™ Supplier No. 45036D5UG

Description

Recombinant Protein

Recombinant Human/Rat Neuritin is a covalently disulfide-linked homodimer, consisting of two 9.72 kDa polypeptide monomers, each containing 88 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Neuritin belongs to the neuritin family and is expressed in postmitotic-differentiating neurons of the developmental nervous system as well as neuronal structures associated with plasticity in adults. Its expression can be induced by neural activity and neurotrophins. The protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins and promotes neurite outgrowth and arborization, indicating its role in promoting neuritogenesis. Overexpression of the protein may be associated with astrocytoma progression. Alternative splicing leads to multiple transcript variants. NRN1 is associated with Severe Congenital Neutropenia 8 and Spinal Muscular Atrophy, Type III.

Specifications

• Accession Number: O08957, Q9NPD7
• For Use With (Application): Functional Assay
• Formulation: protein with no preservative
• Gene ID (Entrez): 51299, 83834
• Molecular Weight (g/mol): 19.4 kDa
• Name: Human/Rat Neuritin
• Quantity: 5 μg
• Source: E. coli
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/ μg
• Gene Alias: 0710008J23Rik; Candidate plasticity gene 15 protein; candidate plasticity-related gene 15; Cpg15; dJ380B8.2; Neuritin; neuritin 1; NRN; NRN1
• Common Name: Neuritin
• Gene Symbol: NRN1
• Biological Activity: Determined by a cell proliferation using rat C6 cells. The ED50 for this effect is 20.0-30.0 ng/ml
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: AGKCDAVFKG FSDCLLKLGD SMANYPQGLD DKTNIKTVCT YWEDFHSCTV TALTDCQEGA KDMWDKLRKE SKNLNIQGSL FELCGSGN
• Content And Storage: -20°C
• Expression System: E. coli
• Form: Lyophilized
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.