Invitrogen™ Human/Rat PSD93 (aa 352-366) Synthetic Peptide

Catalog No.	Quantity
PEP021	50 μg

Catalog No. PEP021 Supplier Invitrogen™ Supplier No. PEP021

Description

Synthetic Peptide

Rat and Human PSD-93 (residues 352-366) Synthetic Peptide, PEP-021, from Invitrogen.

PSD-93, also known as chapsyn-110, is one of a family of plasma membrane-associated proteins found in synaptic junctions. PSD-93 is unique among family members in its expression in Purkinje neuron cell bodies and dendrites. PSD-93 has three ~90 amino acid repeats called PDZ domains, a single interior SH3 domain, and a carboxyl-terminal guanylate kinase homology (GuK) domain that is enzymatically inactive. It is hypothesized that PDZ-domain interactions play a role in receptor and channel clustering which contributes to neuronal plasticiyt. PSD-93 is believed to participate in the clustering of certain proteins, including NMDA receptors and shaker-type potassium channels at the synaptic membrane. There are two principal modes of interaction between PSD-93 and other proteins. NMDA receptors and shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif may interact with PSD-93 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with PSD-93 in vitro through a pseudo-homotypic PDZ-PDZ interaction.

Specifications

• Gene ID (Entrez): 1740, 64053
• Species: Human, Rat
• Purification Method: purified
• Accession Number: Q15700, Q63622
• Common Name: Human/Rat PSD93 (aa 352-366)
• Concentration: 0.5 mg/mL
• Content And Storage: -20°C. Avoid freeze-thaw cycles.
• Description: Synthetic Peptide
• Format: Lyophilized
• Formulation: peptide with no preservative
• For Use With (Application): Control
• Gene Symbol: DLG2
• Lyophilized: Lyophilized
• Preservative: No preservative
• Product Type: Peptide
• Quantity: 50 μg
• Regulatory Status: RUO - research use only
• Sequence: N352 - K - L - C - D - K - P - A - S - P - R - H - Y - S - P366