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STEMCELL Technologies Human Recombinant R-Spondin-1, Size: 1000 µg
Supplier: STEMCELL Technologies 78213.3
Use R-Spondin-1 (RSPO1) to modulate pleiotropic roles during embryogenesis, such as the specification of hematopoietic stem cells (Genthe & Clements. Development, 2017) and the growth, survival, and migration of ovarian cancer cells (Liu et al. Gene, 2019). RSPO1 is the prototype member of the R-Spondin (RSPO) protein subfamily of a superfamily of thrombospondin type 1 repeat (TSR-1)-containing proteins (Kim et al. Cell Cycle, 2006). Although unable to initialize signaling, RSPO family members are potent enhancers of WNT signaling (Cruciat & Niehrs. Cold Spring Harb Perspect Biol, 2013). Through WNT signaling, RSPO1 activates β-catenin signaling and indirectly increases low-density lipoprotein receptor-related protein on the cell surface (Binnerts et al. Proc Natl Acad Sci USA, 2007). Human recombinant R-Spondin-1 from STEMCELL comes lyophilized with ≥ 95% purity; EC50 ≤ 50 ng/mL; endotoxin levels verified ≤ 0.2 EU/μg protein. Alternative names: hRspo1, Roof plate-specific Spondin-1.
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