Invitrogen™ Human Serpin C1 Native Protein

Description

Native Protein

RP-43136 contains native human Antithrombin III protein. RP-43136 may be used as a positive control in many immunological assays. The product is of human blood/plasma origin. Although the starting material was tested prior to initiation of the manufacturing process, and was found negative or nonreactive for anti-HIV-1/2, HIV-1 antigen(s), HBsAg, STS, anti-HCV, anti-HBcore and anti-HTLV I & II, extreme caution should be used when handling this material as there is a margin of error in all tests.

The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.

Specifications

• Accession Number: P01008
• Concentration: 10.7 mg/mL
• For Use With (Application): Control
• Formulation: 50% water with 50% glycerol and no preservative
• Gene ID (Entrez): 462
• Molecular Weight (g/mol): 58 kDa
• Name: Human Serpin C1
• Quantity: 1 mg
• Source: Human
• Regulatory Status: RUO
• Gene Alias: AI114908; antithrombin; Antithrombin 3; anti-thrombin 3; antithrombin III; antithrombin-III; AT3; At-3; AT3D; ATIII; hypothetical protein LOC540261; MGC22579; PRO0309; serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; serpin C1; serpin family C member 1; serpin peptidase inhibitor clade C member 1; serpin peptidase inhibitor, clade C (antithrombin), member 1; serpin peptidase inhibitor, clade C, member 1; Serpinc1; THPH7
• Common Name: SERPINC1
• Gene Symbol: SERPINC1
• Conjugate: Unconjugated
• Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid
• Protein Subtype: Native

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov