Gibco™ Human IL-15 Receptor alpha (soluble) Fc Recombinant Protein, PeproTech®

Catalog No.	Quantity
50-238-7956	20 μg
50-238-7952	1 mg
50-238-7943	250 μg
50-238-7949	100 μg

Catalog No. 50-238-7956 Supplier Gibco™ Supplier No. 20015RA20UG

Description

Recombinant Protein

Recombinant Human sIL-15 Receptor alpha Fc has a calculated molecular weight of 44.4 kDa protein and contains 408 amino acid residues, which consists of the extracellular domain of IL-15R alpha fused to the Fc portion of human IgG. Due to glycosylation, it migrates at an apparent molecular weight of 50-60 kDa, under reducing conditions. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Interleukin 15 (IL-15RA) is a cytokine receptor that specifically binds IL-15 with high affinity. IL-15 regulates T and natural killer cell activation and proliferation. The IL-15 and IL-2 receptors share two subunits, IL-2R beta and IL-2R gamma, and IL-15RA is structurally related to IL-2RA, an additional IL-2-specific alpha subunit necessary for high affinity IL-2 binding. Unlike IL-2RA, IL-15RA is capable of binding IL-15 with high affinity independent of the other subunits. IL-15RA is thought to enhance cell proliferation and expression of apoptosis inhibitor Bcl-xL and Bcl-2.

Specifications

• Accession Number: Q13261
• For Use With (Application): Functional Assay
• Format: Lyophilized
• Formulation: protein with no preservative
• Gene ID (Entrez): 3601
• Molecular Weight (g/mol): 44.4 kDa
• Name: Human IL-15 Receptor alpha (soluble) Fc
• Purification Method: HPLC, SDS-PAGE
• Quantity: 20 μg
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/μg
• Gene Alias: AA690181; CD215; IL 15 receptor; IL 15 receptor subunit a; IL 15 R; IL 15 R alpha; IL 15 R a; IL15 receptor; IL15 receptor subunit alpha; IL-15 receptor subunit alpha; IL15 receptor subunit a; IL15R; IL15R alpha; IL15R a; Il15ra; IL-15 RA; IL-15 R-alpha; Interleukin 15 receptor; interleukin 15 receptor alpha isoform EM2; interleukin 15 receptor alpha isoform IC2; interleukin 15 receptor alpha isoform IC3; interleukin 15 receptor alpha isoform IC4; interleukin 15 receptor alpha isoform IC5; interleukin 15 receptor alpha isoform IC6; interleukin 15 receptor alpha isoform IC7; interleukin 15 receptor alpha isoform IC8; interleukin 15 receptor subunit alpha; Interleukin 15 receptor subunit a; interleukin 15 receptor, alpha; interleukin 15 receptor, alpha chain; interleukin-15 receptor subunit alpha; sIL 15 R; sIL-15 receptor subunit alpha; sIL15R; sIL-15 RA; sIL-15 R-alpha; soluble IL 15 R; soluble IL15R; Soluble interleukin-15 receptor subunit alpha
• Common Name: IL15RA
• Gene Symbol: IL15RA
• Biological Activity: Determined by its ability to inhibit the proliferation of mouse CTLL-2 cells in the presence of Recombinant Human IL-15.
• Product Type: Protein
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Protein Tag: Fc-tag
• Sequence: ITCPPPMSVE HADIWVKSYS LYSRERYICN SGFKRKAGTS SLTECVLNKA TNVAHWTTPS LKCIRDPALV HQRPAPPSTV TTAGVTPQPE SLSPSGKEPA ASSPSSNNTA ATTAAIVPGS QLMPSKSPST GTTEISSHES SHGTPSQTTA KNWELTASAS HQPPGVYPQG HSDTTGGPKS CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSRDELT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGK
• Content And Storage: -20°C
• Activity: Determined by its ability to inhibit the proliferation of mouse CTLL-2 cells in the presence of Recombinant Human IL-15.
• Expression System: Insect cells
• Form: Lyophilized
• Purity or Quality Grade: ≥98% by SDS-PAGE gel and HPLC analyses.