Gibco™ Human TACI Recombinant Protein, PeproTech®

Catalog No.	Quantity
31017250UG	250 μg
31017100UG	100 μg
310-17-20UG	20 μg
31017500UG	500 μg
310-17-5UG	5 μg

Catalog No. 31017250UG Supplier Gibco™ Supplier No. 31017250UG

Description

Recombinant Protein

310-17-1MG will be provided as 2 x 500 μg (310-17-500UG). Recombinant Human TACI is a soluble 159 amino acid polypeptide (17.8 kDa) comprising the TNFR homologous, cysteine-rich extracellular domain of the TACI protein. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 and April/TALL-2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non-immunological cell growth. Three receptors, BCMA, TACI, and BAFF-R, for BAFF and April were recently identified. TACI, like BCMA, binds BAFF and April. TACI and its ligands regulate humoral immune responses, activate NF-kappa-B and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.

Specifications

• Accession Number: O14836
• For Use With (Application): ELISA, Functional Assay, Western Blot
• Formulation: protein with no preservative
• Gene ID (Entrez): 23495
• Molecular Weight (g/mol): 17.8 kDa
• Name: Human TACI
• Quantity: 250 μg
• Source: E. coli
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/ μg
• Gene Alias: 1200009E08Rik; CD267; CVID; CVID2; IGAD2; NEWGENE_1595998; RYZN; TACI; TNF receptor superfamily member 13 B; Tnfrsf13b; TNFRSF14B; transmembrane activator and calcium-modulating and cyclophilin ligand interactor; transmembrane activator and CAML interactor; tumor necrosis factor receptor 13 B; tumor necrosis factor receptor superfamily member 13 B; tumor necrosis factor receptor superfamily, member 13 B
• Common Name: TACI
• Gene Symbol: TNFRSF13B
• Biological Activity: Determined by its ability to block human BAFF induced T2B cell survival using a concentration range of 1.0-3.0 ug/ml
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: SGLGRSRRGG RSRVDQEERF PQGLWTGVAM RSCPEEQYWD PLLGTCMSCK TICNHQSQRT CAAFCRSLSC RKEQGKFYDH LLRDCISCAS ICGQHPKQCA YFCENKLRSP VNLPPELRRQ RSGEVENNSD NSGRYQGLEH RGSEASPALP GLKLSADQV
• Content And Storage: -20°C
• Expression System: E. coli
• Form: Lyophilized
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.