Gibco™ Human TFF-2 Recombinant Protein, PeproTech®

Catalog No.	Quantity
30059100UG	100 μg
300-59-1MG	1 mg
30059250UG	250 μg
30059500UG	500 μg

Catalog No. 30059100UG Supplier Gibco™ Supplier No. 30059100UG

Description

Recombinant Protein

Recombinant Human TFF-2 is a 12.0 kDa polypeptide of 107 amino acid residues, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing and protection of the gastrointestinal epithelia. These peptides contain three intrachain disulfide bonds, forming the trefoil motif, or P-domain. SP (spasmolytic polypeptide), also designated Trefoil factor 2 (TFF2) precursor, is a trefoil protein that functions to inhibit gastrointestinal motility and gastric acid secretion. SP may also act as a structural component of the gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. A downregulation of SP expression is associated with primary gastric cancer, and a progressive loss of this protein is likely to be involved in the early stage of the multi-step gastric carcinogenesis pathway.

Specifications

• Accession Number: Q03403
• For Use With (Application): ELISA, Functional Assay, Western Blot
• Formulation: protein with no preservative
• Gene ID (Entrez): 7032
• Molecular Weight (g/mol): 12 kDa
• Name: Human TFF-2
• Quantity: 100 μg
• Source: E. coli
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/ μg
• Gene Alias: mSP; pancreatic spasmolytic polypeptide; PSP; SML1; SP; spasmolysin; Spasmolytic polypeptide; spasmolytic protein 1; Tff2; Trefoil factor 2; trefoil factor 2 (spasmolytic protein 1)
• Common Name: TFF2
• Gene Symbol: Tff2
• Biological Activity: Assay 1: Determined by its ability to chemoattract human monocytes using a concentration range of 1.0-10.0 ug/ml Assay 2: Determined by its ability to chemoattract human MCF-7 cells using a concentration range of 1.0-10.0 ng/ml
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: AEKPSPCQCS RLSPHNRTNC GFPGITSDQC FDNGCCFDSS VTGVPWCFHP LPKQESDQCV MEVSDRRNCG YPGISPEECA SRKCCFSNFI FEVPWCFFPK SVEDCHY
• Content And Storage: -20°C
• Expression System: E. coli
• Form: Lyophilized
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.