Invitrogen™ Human TGF-beta 3 Recombinant Protein

Catalog No.	Quantity
PIRP8600	10 μg

Catalog No. PIRP8600 Supplier Invitrogen™ Supplier No. RP8600

Description

Recombinant Protein

Recombinant human TGF-beta3 is a non-glycosylated, disulfide-linked homodimer, containing two 112 amino acid chains.

Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.

Specifications

• Accession Number: P10600
• Concentration: 0.25 mg/mL
• For Use With (Application): Control
• Formulation: 0.01 M acetic acid with 20% ethanol and no preservative
• Gene ID (Entrez): 7043
• Molecular Weight (g/mol): 12.9 kDa
• Name: Human TGF-beta 3
• Quantity: 10 μg
• Source: E. coli
• Regulatory Status: RUO
• Endotoxin Concentration: ≤0.1 EU/μg
• Gene Alias: ARVD; ARVD1; FLJ16571; H-TGF-b-3; LAP; Latency-associated peptide; LDS5; prepro-transforming growth factor beta-3; RNHF; TGF beta 3; Tgfb3; TGF-B3; Tgfb-3; TGF-beta3; TGF-beta-3; Transforming growth factor; transforming growth factor beta 3; transforming growth factor beta precursor; transforming growth factor beta-3; Transforming growth factor beta-3 proprotein; transforming growth factor, beta 3; transforming growth factor-beta3
• Common Name: TGF beta-3
• Gene Symbol: TGFB3
• Biological Activity: ED50 =1 ng/mL; determined by the dose-dependent inhibition of HT-2 cell proliferation induced by IL-4.
• Conjugate: Unconjugated
• Species: E. coli
• Recombinant: Recombinant
• Sequence: MALDTNYCFR NLEENCCVRP LYIDFRQDLG WKWVHEPKGY YANFCSGPCP YLRSADTTHS TVLGLYNTLN PEASASPCCV PQDLEPLTIL YYVGRTPKVE QLSNMVVKSC KCS
• Content And Storage: 4°C
• Expression System: E. coli
• Form: Liquid
• Protein Subtype: Recombinant
• Purity or Quality Grade: ≥95%

Safety and Handling

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