Invitrogen™ Human TNF-RI (soluble) Recombinant Protein

Catalog No.	Quantity
PIRP75725	100 μg

Catalog No. PIRP75725 Supplier Invitrogen™ Supplier No. RP75725

Description

Recombinant Protein

This product contains a purified 161 amino acid fragment (aa41-201) corresponding to the mature soluble TNF receptor I protein with an N-terminal hexahistidine tag. This product may be used as a positive control in many immunological assays.

TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily, and is one of the major TNF-alpha receptors. TNFR1 plays an important role in mediating, in cytokine mediated signaling, positive regulation of the NF-Kb pathway, positive regulation of angiogenesis, and negative regulation of gene expression. The extracellular domain of TNFR1 is also released into the circulatory system as soluble TNFR1 (sTNFR1). In humans, the TNFR1 gene is located on chromosome 12. Anti-apoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with TNFR1, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of TNFR1 were found to be associated with the autosomal dominant periodic fever syndrome, and the impaired receptor clearance is thought to be a mechanism of the disease.

Specifications

• Accession Number: P19438
• Concentration: 1.25 mg/mL
• For Use With (Application): Control, Western Blot
• Formulation: 20 mM tris HCl with 1 mM EDTA, 50% glycerol and no preservative; pH 8
• Gene ID (Entrez): 7132
• Molecular Weight (g/mol): 22.68 kDa
• Name: Human TNF-RI (soluble)
• pH Range: 8
• Quantity: 100 μg
• Source: E. coli
• Regulatory Status: RUO
• Gene Alias: CD120a; CD120a antigen; FPF; hypothetical protein; metalloproteinase inhibitor 4; MGC19588; MS5; n-smase activation assoc. factor; p55; p55 TNF receptor; p55-R; p60; p62; p63; sCD120a; soluble CD120a; soluble TNFR1; sTNF RI; sTNFR I; sTNFR1; sTNFRI; TBP1; TBPI; TIMP metallopeptidase inhibitor 4; Timp4; TIMP-4; tissue inhibitor of metalloproteinase 4; tissue inhibitor of metalloproteinases 4; TNF receptor alpha chain; TNF receptor superfamily member 1 A; TNF-alphaR1; TNF-alpha-R1; TNFalpha-R1; TNFAR; TNFR; TNF-R; TNFR I; TNFR1; TNF-R1; Tnfr-1; TNFR1-d2; Tnfr-2; TNFR55; TNF-R55; TNFR60; TNFRI; TNF-RI; TNF-R-I; TNFR-I; TNFRp55; Tnfrsf1a; tumor necrosis factor binding protein 1; Tumor necrosis factor receptor; tumor necrosis factor receptor 1; tumor necrosis factor receptor 1 A isoform beta; tumor necrosis factor receptor superfamily member 1 A; Tumor necrosis factor receptor superfamily member 1 A, membrane form; tumor necrosis factor receptor superfamily, member 1 A; tumor necrosis factor receptor type 1; tumor necrosis factor receptor type I; tumor necrosis factor-alpha receptor; Tumor necrosis factor-binding protein 1
• Common Name: TNFR1
• Gene Symbol: TNFRSF1A
• Conjugate: Unconjugated
• Species: E. coli
• Recombinant: Recombinant
• Protein Tag: His-tag
• Sequence: Amino acids Asp41-Asn201 containing an N-terminal His-tag
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Protein Subtype: Recombinant
• Purity or Quality Grade: >95%, by SDS-PAGE under reducing conditions