Gibco™ Human TREM-1 Fc Recombinant Protein, PeproTech®

Catalog No.	Quantity
310-36-50UG	50 μg
31036100UG	100 μg
310-36-10UG	10 μg
310-36-1MG	1 mg
31036250UG	250 μg
31036500UG	500 μg

Catalog No. 310-36-50UG Supplier Gibco™ Supplier No. 3103650UG

Description

Recombinant Protein

PeproTech's CHO cell-derived Recombinant Human TREM-1 Fc is a glycosylated, disulfide-linked homodimer of 826 amino acid residues whose monomer consists of the 180-amino-acid length extracellular portion of TREM-1 fused to the 231-amino-acid length Fc portion of human IgG1 by two glycines. The calculated molecular weight of Recombinant Human TREM-1 Fc dimer is 92.6 kDa; however, due to glycosylation, the monomer and dimer migrate at apparent molecular weights of approximately 60-65 kDa and 110-116 kDa by SDS-PAGE analysis under reducing conditions. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

TREM1 (triggering receptor expressed on myeloid cells 1) is a receptor belonging to the Ig superfamily that amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. It is thought that TREM1 other related TREM proteins such as TREM2 act to modulate the inflammatory response. TREM1 has also been linked to inflammatory bowel disease resulting in enhanced production of TNF, IL-6, IL-8, and MCP-1.

Specifications

• Accession Number: Q9NP99
• For Use With (Application): Functional Assay
• Formulation: protein with no preservative
• Gene ID (Entrez): 54210
• Molecular Weight (g/mol): 92.6 kDa
• Name: Human TREM-1 Fc
• Quantity: 50 μg
• Source: CHO cells
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/ μg
• Gene Alias: CD354; sCD354; soluble CD354; soluble TREM 1; soluble TREM1; sTREM 1; sTREM1; TREM; Trem1; TREM-1; triggering receptor expressed in monocytes 1; triggering receptor expressed on monocytes 1; Triggering receptor expressed on myeloid cells; Triggering receptor expressed on myeloid cells 1
• Common Name: TREM1
• Gene Symbol: TREM1
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Protein Tag: Fc-tag
• Sequence: ATKLTEEKYE LKEGQTLDVK CDYTLEKFAS SQKAWQIIRD GEMPKTLACT ERPSKNSHPV QVGRIILEDY HDHGLLRVRM VNLQVEDSGL YQCVIYQPPK EPHMLFDRIR LVVTKGFSGT PGSNENSTQN VYKIPPTTTK ALCPLYTSPR TVTQAPPKST ADVSTPDSEI NLTNVTDIIR GGPKSCDKTH TCPPCPAPEL LGGPSVFLFP PKPKDTLMIS RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE QYNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKALPAPIEK TISKAKGQPR EPQVYTLPPS RDELTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSKLTVDK SRWQQGNVFS CSVMHEALHN HYTQKSLSLS PGK
• Content And Storage: -20°C
• Expression System: CHO cells
• Form: Lyophilized
• Purity or Quality Grade: ≥ 95% by SDS-PAGE gel and HPLC analyses.