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Gibco™ Human TSG Recombinant Protein, PeproTech®

Catalog No. 12009250UG
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Catalog No. Quantity
12009250UG 250 μg
12009100UG 100 μg
120-09-10UG 10 μg
120-09-1MG 1 mg
12009500UG 500 μg
120-09-50UG 50 μg
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Catalog No. 12009250UG Supplier Gibco™ Supplier No. 12009250UG
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Description

Recombinant Protein

Recombinant Human TSG is a 198 amino acid, 22.2 kDa protein containing the BMP/TGF-beta binding portion of the full length TSG protein. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

TWSG1 may be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q9GZX9
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 57045
Molecular Weight (g/mol) 22.2 kDa
Name Human TSG
Quantity 250 μg
Source E. coli
Regulatory Status RUO
Endotoxin Concentration <1 EU/ μg
Gene Alias 1810013J15Rik; 9030422N06Rik; AW552143; D17Ertd403e; PSEC0250; Tsg; Twg; twisted gastrulation BMP signaling modulator 1; twisted gastrulation homolog 1; twisted gastrulation homolog 1 (Drosophila); twisted gastrulation protein homolog 1; Twsg1
Common Name TSG
Gene Symbol Twsg1
Biological Activity Determined by its ability to neutralize BMP-6-induced alkaline phosphatase production by ATDC chondrogenic cells. The expected ED50 for this effect is ≤ 2.0 ug/ml of TSG.
Conjugate Unconjugated
Recombinant Recombinant
Sequence CNKALCASDV SKCLIQELCQ CRPGEGNCSC CKECMLCLGA LWDECCDCVG MCNPRNYSDT PPTSKSTVEE LHEPIPSLFR ALTEGDTQLN WNIVSFPVAE ELSHHENLVS FLETVNQPHH QNVSVPSNNV HAPYSSDKEH MCTVVYFDDC MSIHQCKISC ESMGASKYRW FHNACCECIG PECIDYGSKT VKCMNCMF
Content And Storage -20°C
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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