Invitrogen™ Human TTBK2 Synthetic Peptide

Catalog No.	Quantity
PEP1412	50 μg

Catalog No. PEP1412 Supplier Invitrogen™ Supplier No. PEP1412

Description

Synthetic Peptide

TTBK2 Synthetic Peptide, PEP-1412, from Invitrogen.

Tau tubulin kinase (TTBK2) is a serine/threonine kinase whose substrates are thought to include the tau and tubulin proteins. Mutations in the TTBK2 gene cause spinocerebellar ataxia type 11 (SCA11), a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. Recent studies have shown that increased levels of TTBK2 expression in kidney carcinoma and melanoma cell lines increases resistance to the chemotherapeutic agent Sunitinib, and that reduction of TTBK2 though the use of siRNA sensitized these cell lines to the effects of Sunitib, suggesting that TTBK2 can be used as a resistance marker as well a potential target to overcome resistance.

Specifications

• Gene ID (Entrez): 146057
• Species: Human
• Purification Method: purified
• Accession Number: Q6IQ55
• Common Name: Human TTBK2
• Concentration: 200 μg/mL
• Content And Storage: -20°C
• Description: Synthetic Peptide
• Format: Liquid
• Formulation: PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
• For Use With (Application): Blocking Assay, Control
• Gene Symbol: TTBK2
• Lyophilized: No
• Preservative: 0.02% sodium azide
• Product Type: Peptide
• Quantity: 50 μg
• Regulatory Status: RUO - research use only
• Storage Buffer: PBS