Gibco™ Human TWEAK Receptor Recombinant Protein, PeproTech®

Description

Recombinant Protein

Recombinant Human soluble TWEAKR is a 53 amino acid polypeptide (5.6 kDa) comprising the entire extracellular domain of the full-length TWEAKR protein. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

TWEAK is a member of the TNF family and was first described as a weak inducer of apoptosis in demonstrate that this relatively small molecule is a fully transformed cell lines. Recently, a receptor for TWEAK was isolated by expression cloning from a HUVEC cell cDNA library. TweakR is a small protein belonging to TNF receptor super family. TweakR is capable of intiating a proliferative signal by binding to TRAF1, 2, and 3. TweakR mRNA is upregulated during tissue regeneration in the aorta and liver. It may also play a role in vascular cell migration and angiogenesis.

Specifications

• Accession Number: Q9NP84
• For Use With (Application): Functional Assay
• Formulation: protein with no preservative
• Gene ID (Entrez): 51330
• Molecular Weight (g/mol): 5.6 kDa
• Name: Human TWEAK Receptor
• Quantity: 1 mg
• Source: E. coli
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/ μg
• Gene Alias: AI255180; C87282; CD266; FGF-inducible 14; Fgfrp2; fibroblast growth factor regulated protein 2; fibroblast growth factor-inducible immediate-early response protein 14; Fibroblast growth factor-regulated protein 2; FN14; HPIP; TNF receptor superfamily member 12 A; TNFRSF12A; Tumor necrosis factor receptor superfamily member 12 A; tumor necrosis factor receptor superfamily, member 12 A; TweakR; TWEAK-R; Tweak-receptor; type I transmembrane protein Fn14
• Common Name: CD266
• Gene Symbol: TNFRSF12A
• Biological Activity: Determined by its ability to inhibit TWEAK-induced weak cell death of HT29 cells. The expected ED50 for this effect is 1.0-3.0 ug/ml
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP
• Content And Storage: -20°C
• Expression System: E. coli
• Form: Lyophilized
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.