R&D Systems™ Human VHL (NP_000542) VersaClone cDNA

Catalog No.	Quantity
RDC2745	10 μg

Catalog No. RDC2745 Supplier R&D Systems™ Supplier No. RDC2745

Description

This shuttle vector contains the complete ORF for the gene of interest, along with a Kozak consensus sequence for optimal translation initiation. It is inserted NotI to AscI. The gene insert is flanked with convenient multiple cloning sites which can be used to easily cut and transfer the gene cassette into your desired expression vector.

• Also known as: RCA1; VHL1; pVHL; HRCA1
• Von Hippel Lindau, VHL, is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity.
• VHL is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF).
• RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of VHL.
• VHL is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors.
• Alternatively spliced transcripts encoding different proteins have been described.
• The insert is sequence verified and the entire plasmid DNA and insert translated sequences are provided.
• For reasearch use only. Not for use in humans.

Specifications

• Gene: hVHL
• Accession Number: NP_000542
• Concentration: 10 μg at 0.2 μg/μL
• Formulation: cDNA is provided in 10 mM Tris-Cl, pH 8.5
• Insert Type: 655 bp
• Gene ID (Entrez): 7428
• Content And Storage: Store the unopened product at -20°C to -70°C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
• Species: Human
• Quantity: 10 μg