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Invitrogen™ Humanin Polyclonal Antibody
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Catalog No. 01675227
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100 μL
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01-675-227 100 μL
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Catalog No. 01-675-227 Supplier Invitrogen™ Supplier No. PA141610
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Description

Rabbit Polyclonal Antibody

Suggested positive control: recombinant fusion protein.

Humanin is a novel 24 A. A polypeptide identified in Alzheimer's disease-affected brain. It is 99% homologous to mitochondrial 16s ribosomal RNA and functions as a novel neuroprotective and cytoprotective factor. It specifically inhibits neuronal cell death induced by beta-amyloids and Alzheimer's disease causing FAD genes by competitively inhibiting access of FPRL1 receptor to beta-amyloids. It acts as an anti-apoptotic factor by binding to Bcl-2/Bax family of pro-apoptotic factors including Bax, Bak, Bid and BimEL and inhibits their pro-apoptotic activity. It activates JAK/STAT signaling pathway and is regulated by TRIM11. It interacts with IGFBP-3 and specifically blocks IGFBP-3 induced cell death in glioblastoma cells. Humanin is also expressed in colon and testis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Humanin
Applications ELISA, Western Blot
Classification Polyclonal
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Whole serum with 50% glycerol and 0.025% sodium azide
Gene MT-RNR2
Gene Accession No. Q8IVG9
Gene Alias BCL2L4; HN1; Humanin-like 1; humanin-like protein 1; mitochondrially encoded 16S RNA; MTRNR2; MT-RNR2; MTRNR2L1; MT-RNR2-like 1; MTRNR2-like 1; MT-RNR2-like protein 1; RNR2
Gene Symbols MT-RNR2
Host Species Rabbit
Immunogen Amino acids 12-24 of human humanin protein.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4550
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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