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Invitrogen™ Humanin Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA141610
Description
Suggested positive control: recombinant fusion protein.
Humanin is a novel 24 A. A polypeptide identified in Alzheimer's disease-affected brain. It is 99% homologous to mitochondrial 16s ribosomal RNA and functions as a novel neuroprotective and cytoprotective factor. It specifically inhibits neuronal cell death induced by beta-amyloids and Alzheimer's disease causing FAD genes by competitively inhibiting access of FPRL1 receptor to beta-amyloids. It acts as an anti-apoptotic factor by binding to Bcl-2/Bax family of pro-apoptotic factors including Bax, Bak, Bid and BimEL and inhibits their pro-apoptotic activity. It activates JAK/STAT signaling pathway and is regulated by TRIM11. It interacts with IGFBP-3 and specifically blocks IGFBP-3 induced cell death in glioblastoma cells. Humanin is also expressed in colon and testis.
Specifications
Humanin | |
Polyclonal | |
Unconjugated | |
MT-RNR2 | |
BCL2L4; HN1; Humanin-like 1; humanin-like protein 1; mitochondrially encoded 16S RNA; MTRNR2; MT-RNR2; MTRNR2L1; MT-RNR2-like 1; MTRNR2-like 1; MT-RNR2-like protein 1; RNR2 | |
Rabbit | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
ELISA, Western Blot | |
Conc. Not Determined | |
whole serum with 50% glycerol and 0.025% sodium azide | |
Q8IVG9 | |
MT-RNR2 | |
Synthetic peptide corresponding to residues 12-24 of human humanin. | |
RUO | |
4550 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
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