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Invitrogen™ Humanin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA141610

Catalog No. 01-675-227


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Description

Description

Suggested positive control: recombinant fusion protein.

Humanin is a novel 24 A. A polypeptide identified in Alzheimer's disease-affected brain. It is 99% homologous to mitochondrial 16s ribosomal RNA and functions as a novel neuroprotective and cytoprotective factor. It specifically inhibits neuronal cell death induced by beta-amyloids and Alzheimer's disease causing FAD genes by competitively inhibiting access of FPRL1 receptor to beta-amyloids. It acts as an anti-apoptotic factor by binding to Bcl-2/Bax family of pro-apoptotic factors including Bax, Bak, Bid and BimEL and inhibits their pro-apoptotic activity. It activates JAK/STAT signaling pathway and is regulated by TRIM11. It interacts with IGFBP-3 and specifically blocks IGFBP-3 induced cell death in glioblastoma cells. Humanin is also expressed in colon and testis.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Humanin
Polyclonal
Unconjugated
MT-RNR2
BCL2L4; HN1; Humanin-like 1; humanin-like protein 1; mitochondrially encoded 16S RNA; MTRNR2; MT-RNR2; MTRNR2L1; MT-RNR2-like 1; MTRNR2-like 1; MT-RNR2-like protein 1; RNR2
Rabbit
100 μL
Primary
Human
Antibody
IgG
ELISA, Western Blot
Conc. Not Determined
whole serum with 50% glycerol and 0.025% sodium azide
Q8IVG9
MT-RNR2
Synthetic peptide corresponding to residues 12-24 of human humanin.
RUO
4550
-20°C, Avoid Freeze/Thaw Cycles
Liquid
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