PD-L1/CD274 Rabbit Recombinant Antibody (83-216), ProSci

Catalog No.	Quantity
16-841-910	100 μg

Catalog No. 16-841-910 Supplier ProSci LLC Supplier No. 832160100

Description

Rabbit Monoclonal Antibody

This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.

Specifications

• Antigen: PD-L1/CD274
• Applications: ELISA, Immunofluorescence, Inhibition Assays, Western Blot
• Classification: Monoclonal
• Conjugate: Unconjugated
• Formulation: Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
• Gene Accession No.: Q9NZQ7
• Host Species: Rabbit
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 29126
• Target Species: Human
• Content And Storage: Store at -20°C. Avoid freeze / thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG
• Shipping Condition: Dry Ice
• Research Category: CDs, Immunology Inflammation
• Product Line: ProSci