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Apexbio Technology LLC Hydroxyfasudil hydrochloride 155558-32-0 50mg
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Supplier:  Apexbio Technology LLC A347950

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Hydroxyfasudil hydrochloride (CAS 155558-32-0) is a metabolite of fasudil and a potent inhibitor of Rho-associated protein kinases exhibiting IC50 values of 0 12 M for ROCK1 and 0 17 M for ROCK2 By inhibiting Rho-kinase activity hydroxyfasudil modulates vascular tone and cellular hypertrophy In cellular assays it prevents endothelin-induced cardiomyocyte hypertrophy and mitigates serotonin-induced vasoconstriction In animal models hydroxyfasudil improves bladder function attenuates histopathological changes in cystitis and restores penile cGMP levels while regulating vascular responses These properties support its use in studies of cardiovascular urological and vascular pathophysiology

Catalog No. 50-000-97111


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