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Invitrogen™ HYOU1 Polyclonal Antibody
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Catalog No. PIPA527655
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100 μL
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PIPA527655 100 μL
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Catalog No. PIPA527655 Supplier Invitrogen™ Supplier No. PA527655
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: MCF-7, MDA-MB-231, mouse liver, rat brain. Predicted reactivity: Mouse (92%), Rat (90%), Bovine (89%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

HYOU1 belongs to the heat shock protein 70 family. The protein is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HYOU1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.41 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene HYOU1
Gene Accession No. Q63617, Q9JKR6, Q9Y4L1
Gene Alias 140 kDa Ca(2+)-binding protein; 150 kDa oxygen-regulated protein; 150-kDa oxygen regulated protein; 170 kDa glucose regulated protein GRP170; 170 kDa glucose-regulated protein; AI415631; Cab140; calcium binding protein 140; calcium binding protein, 140 kDa; CBP-140; DKFZp686N08236; FLJ94899; FLJ97572; Grp 170; Grp170; GRP-170; HSP 12A; HSP12A; HYOU1; hypoxia up-regulated 1; hypoxia up-regulated protein 1; Orp 150; Orp150; ORP-150; oxygen regulated protein (150kD)
Gene Symbols HYOU1
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the C-terminus region of human ORP150. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10525, 12282, 192235
Target Species Human, Mouse, Plant, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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